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How Covid-19 Testing Can Become More Efficient
How the immune system remembers viruses
Fungus produces highly effective surfactant
Safely on the way to effective tumour cell killing
Secure nano-carrier delivers medications directly to cells
Finding cortisone alternatives with fewer side effects
Intermittent Claudication: EffPac trial confirms benefit and safety of paclitaxel-coated balloon catheter
Researchers solve a long-standing problem in organic chemistry
The tricks of the immune system
A newly discovered disease may lead to better treatment of cystic fibrosis
Remdesivir effective against Covid-19 even after short treatment periods
Frankincense reprograms inflammatory enzyme
Major Depression: Early Prognosis for Ketamine Therapy
Nature as a model: Producing novel active substances more effectively
Researchers develop software for drug repurposing
In-ear sensors to help in fight against COVID-19
Pharmacology
Results 1 - 20 of 24.
Health - Pharmacology - 17.12.2020
Breathing rate predicts therapeutic benefits for heart patients
Discovering a forgotten biosignal Conditions causing arrhythmia are among the most common cardiac conditions. A study headed by Prof. Georg Schmidt of the Technical University of Munich (TUM) has demonstrated for the first time that the nocturnal respiratory rate can help with an important prediction: It is an indicator of whether a defibrillator will help to extend the life of patients with arrhythmia.
Health - Pharmacology - 05.12.2020

With the help of so-called pooling procedures, samples from different people can be combined into a pool and tested for Covid-19 collectively in a single test kit. An interdisciplinary team of mathematicians, computer scientists and medical doctors from the Junge Akademie, the Technische Universität Braunschweig, the Universität Stuttgart and the company Arctoris has developed a decision support tool that calculates which method is most effective in identifying all Covid-19 patients in a positive sample pool.
Health - Pharmacology - 02.11.2020

Immune response: memory T cells are formed earlier than previously thought For a person to acquire immunity to a disease, T cells must develop into memory cells after contact with the pathogen. Until now, the number of cells that do this was believed to depend above all on the magnitude of the initial immune response.
Pharmacology - Health - 23.10.2020
Is Antimicrobial Resistance Evolution Accelerating?
A team of researchers from Freie Universität Berlin and ETH Zurich studied if antifungal and antibiotic resistance emerge faster than in the past No 199/2020 from Oct 23, 2020 Scientists from Freie Universität Berlin and Eidgenössische Technische Hochschule Zürich (ETH Zurich) investigated how long it takes for resistance to emerge after the introduction of a new antifungal or antibiotic.
Pharmacology - Life Sciences - 22.10.2020

Research team discovers previously unknown natural products in soil fungus Mortierella alpina. Life Mortierella alpina lives in the soil and likes to keep cool. This fungus, which belongs to the zygomycetes, grows best at temperatures of 10 to 15°C and occurs mainly in alpine or arctic habitats. In biotechnology, the fungus has been used for the large-scale production of polyunsaturated fatty acids such as arachidonic acids, mainly used as a dietary supplement in baby foods.
Health - Pharmacology - 13.10.2020

Scientists at the University of Göttingen develop drug for antibody tumour therapy Chemists at the University of Göttingen have developed new cytotoxic drugs which could revolutionise antibody-based tumour therapy approaches. The research team succeeded in modifying the natural product Duocarmycin into -prodrug- formats - which means that it only develops its effect once inside the tumour cell, thus reducing the likelihood of potential side effects on passage through the body.
Pharmacology - Health - 25.09.2020

Nanoparticles with synthetic DNA can control release of drugs Medications often have unwanted side-effects. One reason is that they reach not only the unhealthy cells for which they are intended, but also reach and have an impact on healthy cells. Researchers at the Technical University of Munich (TUM), working together with the KTH Royal Institute of Technology in Stockholm, have developed a stable nano-carrier for medications.
Pharmacology - Life Sciences - 02.09.2020

DNA binding is essential for effectiveness of steroids Many people use cortisone of a regular basis. It is used for treating rheumatism, asthma, multiple sclerosis, or even COVID-19. Steroidal medication such as cortisone is highly effective but also possesses severe side effects. Henriette Uhlenhaut, professor at Technical University of Munich (TUM), and her team are examining the beneficial effects of cortisone in order to lay the groundwork for the development of similar drugs with fewer side effects.
Pharmacology - Health - 07.08.2020

A study to balloon angioplasty with drug-coated and uncoated balloons in vascular occlusion in the femoropopliteal region proves the drug-coated devices to be superior Balloon angioplasty is the treatment option for the advanced stage of intermittent claudication - if medication and targeted training can no longer alleviate the pain and impairments caused by constricted leg arteries.
Chemistry - Pharmacology - 16.07.2020

Chemists at the University of Münster develop a bioinspired strategy for the controlled synthesis of polyenes / Study published in "Science" They occur in nature, are reactive and play a role in many biological processes: polyenes. It is no wonder that chemists have for a long time been interested in efficiently constructing these compounds - not least in order to be able to use them for future biomedical applications.
Health - Pharmacology - 23.06.2020

How the T-cell response changes in chronic virus infections "The Covid-19 pandemic clearly demonstrates the importance of understanding how the immune system reacts to virus infections," says Dr. Kilian Schober. Together with an interdisciplinary team of researchers from Medicine, Biology and Bioinformatics, he is investigating how important agents in the body's immune system known as T lymphocytes or T cells react when a virus invades the organism and how the immune response changes when the infection becomes chronic.
Pharmacology - Health - 05.06.2020

Cystic fibrosis is the most frequent severe inherited disorder worldwide. Every year, hundreds of families are confronted with this diagnosis - and to date, there is no cure for this disease that mainly affects the respiratory system. Besides supportive treatments, a lung transplant is often the only option to save a patient's live.
Health - Pharmacology - 03.06.2020

Comparable clinical results after five and ten days of treatment In an international study, scientists from eight countries have investigated the use of the medication Remdesivir in the treatment of Covid-19. One result of the study, which included the participation of the Technical University of Munich's university hospital TUM Klinikum rechts der Isar: The changes in the clinical condition of patients treated for five days were comparable to the changes in patients treated for a period of ten days.
Life Sciences - Pharmacology - 11.05.2020

Research team has clarified the anti-inflammatory effect of a natural product from frankincense resin Life A research team from the University of Jena and Louisiana State University (USA) has clarified the molecular mechanism behind the anti-inflammatory effect of a natural product from frankincense resin.
Pharmacology - Life Sciences - 01.05.2020
An Alternative for Antibiotics
International Team of Researchers Investigates Antibacterial Effects of Antimicrobial Peptides No 073/2020 from May 01, 2020 Scientists at Cornell University, Georgetown University, and Freie Universität Berlin have analyzed and summarized to what extent antimicrobial peptides, such as those found in plants and animals, can be used as an alternative to conventional antibiotics.
Pharmacology - Life Sciences - 29.04.2020

Jena University Hospital coordinates a European research network that aims at establishing therapeutic biomarkers for treatment response to ketamine The World Health Organization estimates that more than 4 million people in Germany suffer from depression. Standard therapy is working insufficiently in one third of patients; in another third, it does not work at all.
Life Sciences - Pharmacology - 29.04.2020

Multi-resistant germs can cause severe infections, particularly in people with a weakened immune system, and are difficult to treat with conventional antibiotics. Novel active substances with anti-infective and sometimes antibiotic effects such as violacein are promising candidates for a remedy, but it has so far been difficult to produce them in sufficient quantities.
Pharmacology - Computer Science - 27.04.2020

Currently, the corona pandemic is dominating the entire social life in Germany and in many other parts of the world. We are working flat out in order to better help the more than one hundred thousand seriously ill people in hospitals. One promising approach to extending current treatment methods is to use existing and approved drugs to combat the virus.
Health - Pharmacology - 24.04.2020
Parasite larvae could help fight allergies
Our immune system protects us against pathogens. However, an excessive immune reaction can trigger allergies or chronic asthma. Scientists at the Technical University of Munich (TUM) and Helmholtz Zentrum München have discovered an active ingredient taken from the larvae of a worm parasite that could help diminish immune reactions.
Health - Pharmacology - 21.04.2020

A team at the Technical University of Munich (TUM) plans to use high-tech biometric sensors for 24-hour monitoring of COVID-19 patients in home isolation. The goal of the study is to find out whether rapid treatment in response to deteriorating vital signs can improve the chance of survival and ease the workload of intensive care units.
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