Retinal blood vessels in a control and during targeted deactivation of SRF in smooth muscle cells. In the control, the arteries (A) merge smoothly into tiny microvessels. These in turn lead to the veins (V), which return the blood to the heart. In SRF-inactivated smooth muscle cells, the arteries largely bypass the microvessels and lead directly to the veins. This shortcut results in reduced blood supply to the surrounding tissue. Black bar (bottom right) corresponds to 1 mm.
Retinal blood vessels in a control and during targeted deactivation of SRF in smooth muscle cells. In the control, the arteries (A) merge smoothly into tiny microvessels. These in turn lead to the veins (V), which return the blood to the heart. In SRF-inactivated smooth muscle cells, the arteries largely bypass the microvessels and lead directly to the veins. This shortcut results in reduced blood supply to the surrounding tissue. Black bar ( bottom right ) corresponds to 1 mm. The heart pumps blood through the vascular system, supplying cells with oxygen and energy Smooth muscle cells in the vessels finely regulate the blood flow.
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