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A research team from RWTH Aachen University has impressively demonstrated the effectiveness of nanoparticle-based combination therapies in cancer treatment in a recent study. The results have now been published in the renowned journal Nature Nanotechnology . The work by Karina Benderski, Prof. Twan Lammers and Alexandros Marios Sofias from the Institute of Experimental Molecular Imaging is the first comprehensive quantitative analysis of so-called multi-drug nanomedicine.

Nanoparticle Combination Therapies Significantly Enhance Tumor Growth Inhibition. In a study recently published in the journal Nature Nanotechnology, researchers at RWTH demonstrate the effectiveness of multi-drug nanomedicine for cancer treatment. Their findings highlight a major step forward in translational research and could help shape new treatment protocols in oncology.

A research team at the Carl Ludwig Institute of Physiology at Leipzig University has shown for the first time how the energy content of individual nerve cells in the brain changes during so-called depolarization waves, waves of activity that occur in various brain diseases. The results provide an important basis for understanding the energy metabolism in the event of an acute lack of blood flow, such as occurs in strokes.

When the cellular waste disposal system goes on strike, this can have fatal consequences. A research team at the University of Würzburg has now identified a key player in this clean-up crew. A special enzyme - the so-called ubiquitin-selective unfoldase p97/VCP - is one of the main players when cells remove malformed or excess proteins from their interior.

Analysing the gene activity of every single bacterial cell in a colony? A new technique from Würzburg can do this much more efficiently than other methods. Not all'individuals in a population of bacteria are identical. Some may be on the verge of cell division, others are differentiating, others are in the process of adapting to changing environmental conditions.

Study of twins detects bacteria in the small intestine that play a role in the development of MS To the point Twin study : Among many other factors, microorganisms in the gut are suspected of contributing to the onset of MS. To obtain meaningful results, researchers examined stool samples and microorganisms directly from the small intestine of identical twins, where only one twin had MS.

Bonn researchers develop method for describing and predicting critical transitions in networked systems The global climate is in an imbalance. Potential "tipping elements " include the Greenland ice sheet, coral reefs, and the Amazon rainforest. Together they form a network that can collapse if just one individual component tips.

The marine worm Ramisyllis multicaudata , which lives within the internal canals of a sponge, is one of only two such species possessing a branching body, with one head and multiple posterior ends. An international research team led by the Universities of Göttingen and Madrid is the first to describe the internal anatomy of this intriguing animal.

Bonn researchers link immune cells to higher risk of duodenal carcinoma in hereditary FAP People with the hereditary disease familial adenomatous polyposis (FAP) have a greatly increased risk of developing a malignant tumor of the duodenum. Researchers at the University Hospital Bonn (UKB) and the Cluster of Excellence ImmunoSensation2 at the University of Bonn have now discovered a mechanism in the local immune system that can drive the development of cancer.

University of Bonn-guided study leads to the discovery of a promising receptor blocker Irritable bowel syndrome, chronic itching, asthma and migraine are in many cases hard-to-treat conditions. They have in common that they are triggered by an excessive immune response-which in severe cases can be life-threatening.

Researchers at the MPI of Biochemistry have used spatial Deep Visual Proteomics workflow to reveal why some patients with the hereditary disease alpha-1 antitrypsin deficiency remain healthy despite the genetic defect.

New insights into dopamine in focal cortical dysplasia: For the first time, a research team in Bonn is systematically investigating the role of the dopamine system in a common form of therapy-resistant epilepsy. Focal cortical dysplasia (FCD) type 2 is a congenital malformation of the cerebral cortex that is often associated with difficult-to-treat epilepsy.

Pathogenic salmonella inject effector proteins into the cells of the stomach and intestinal tissue in order to penetrate and multiply there. The bacteria, which are usually ingested with food, cause dangerous gastrointestinal inflammation and even systemic infections, especially in children and the elderly.

Researchers at the university hospitals in Jena, Aachen, Essen, Halle and Leipzig have developed an app that supports doctors in the treatment of bloodstream infections with staphylococci. The app was evaluated in a large prospective multicentre study at five university hospitals with more than 5,000 patients.

A team from the Max Planck Research Group for Systems Immunology at the University of Würzburg has identified a previously unknown phase of the immune response. These new insights have significant implications for the development of vaccines and cellular immunotherapies. The research groups led by Wolfgang Kastenmüller and Georg Gasteiger employed innovative microscopy techniques to observe how specific immune cells, known as T'cells, are activated and proliferate during a viral infection.

The detection of peripheral neural stem cells could transform the treatment of Parkinson's disease and spinal cord injuries To the point Peripheral neural stem cells: Researchers have discovered a new type of neural stem cell in the lungs of mice. These cells have similar properties to the known neural stem cells in the brain, including self-rejuvenation and differentiation ability.

To the point Induction of Multicellularity : When mechanically compressed, the salt-loving archaeon Haloferax volcanii can shift from being single-celled to forming tissue-like clusters, displaying new mechanical and biological properties. Insights into Evolution : This study challenges current thinking about evolution by showing that physical forces and genetic changes can work together to promote the development of complex life forms, suggesting that multicellularity might arise more easily than we previously imagined.

Research team led by Göttingen University challenges conventional poverty metrics   Two billion people globally suffer from moderate to severe food insecurity and widespread micronutrient deficiencies. This contrasts with 654 million people who are classified as extremely poor according to the World Bank's US$2.15 per day International Poverty Line (IPL).

To the point A neuroimaging study examined the processing of pain signals in the brain as participantswatched virtual nature videos. Participants reported less pain and showed lower activity in brain regions associated with specific pain processing. The findings underscore the importance of nature-based therapeutic approaches in pain management.

Würzburg researchers present a new strategy against the life-threatening fungus Aspergillus fumigatus. They combine RNA molecules and an antifungal agent in nanoparticles. Fungal infections are on the rise globally. According to a study by the Manchester Fungal Infection Group , in 2022, approximately 6.5 million people were infected by a pathogenic fungus, and about 3.8 million died as a result - nearly twice as many as in 2012.