New mechanism of force transduction in muscle cells discovered

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The picture shows focal adhesions (red/blue), in which metavinculin connects to
The picture shows focal adhesions (red/blue), in which metavinculin connects to the intracellular actin cytoskeleton (green). © Carsten Grashoff
Researchers of Münster University reveal mechanobiological function of muscle-specific adhesion protein / Study published in "Nature Communications"

The ability of cells to sense and respond to their mechanical environment is critical for many cellular processes but the molecular mechanisms underlying cellular mechanosensitivity are still unclear. Researchers at the University of Münster have now discovered how the muscle-specific adhesion molecule metavinculin modulates mechanical force transduction on the molecular level. The research results have just been published in the journal "Nature Communications". ...
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