Blood vessels are the pioneers of bone formation in the skull

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Blood vessels (green) have completely vascularized the bone injury (blue), while
Blood vessels (green) have completely vascularized the bone injury (blue), while bone cells (red) are just beginning to form new bone. MPI for Molecular Biomedicine/ Gabriele Bixel
Living bone is fascinating because of its unique ability to adapt to mechanical stress and regenerate without scarring. During fracture healing, blood vessels and bone cells work closely together to gradually replace the initial cartilaginous wound tissue with ingrowing blood vessels and new bone tissue. The bone progenitor cells closely follow the course of the newly formed vessels, an observation known as angiogenic-osteogenic coupling. This is how a broken leg heals. ...
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