View of infected lung tissue (image A) Image Credit: Dietert, Gruber l Freie Universität Berlin.
View of infected lung tissue (image A) Image Credit: Dietert, Gruber l Freie Universität Berlin. Model to serve as basis for new therapeutic strategies / Joint press release by Charité - Universitätsmedizin Berlin, the MDC, and Freie Universität Berlin Covid-19 disease severity is determined by the individual patient's immune response. The precise mechanisms taking place inside the lungs and blood during the early phase of the disease, however, remain unclear. Researchers from Charité - Universitätsmedizin Berlin, the Max Delbrück Center for Molecular Medicine (MDC), and Freie Universität Berlin have now studied the cellular mechanisms taking place at the onset of inflammatory lung injury caused by SARS-CoV-2 infection. Their findings suggest that lung injury requiring mechanical ventilation does not arise as a direct result of the damage caused by the proliferating virus. Writing ( doi.org/10.1038/s41467-021-25030-7 ) , the researchers report that inflammatory processes involving lung endothelial cells appear to play a crucial role in disease severity. Researchers from around the globe have spent the past 18 months trying to understand Covid-19, the disease caused by the SARS-CoV-2 coronavirus.
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