Mikael Simons is for Molecular Neurobiology at TUM. Image: A. Eckert / TUM
Mikael Simons is for Molecular Neurobiology at TUM. Image: A. Eckert / TUM Coronavirus: Neuropilin-1 could open the door to the inside of the cell - The protein neuropilin-1 facilitates SARS CoV-2 cell entry. A research team including Prof. Mikael Simons of the Technical University of Munich (TUM) recently published these findings in the journal "Science". Because neuropilin-1 is expressed in the mucous membranes of the olfactory and respiratory tract, the findings may be important for understanding the spreading of SARS CoV-2. The degree to which a virus spreads depends on its infectivity. While the coronavirus SARS-CoV-2 has led to severe pandemic, a related virus, SARS-CoV, led to a much smaller outbreak in 2003, possibly because the infection was limited to the lower respiratory system. SARS-CoV-2, in contrast, infects the upper portions of the respiratory tract, including the nasal mucous membrane and, in consequence, spreads rapidly through active viral shedding.
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