news

Many hospitals use the adsorber to purify the blood of seriously ill patients in order to trap inflammatory substances and prevent the life-threatening cytokine storm. Many hospitals use the adsorber to purify the blood of seriously ill patients in order to trap inflammatory substances and prevent the life-threatening cytokine storm.

The ATMP-GMPDU development unit at the Institute for Cell Therapeutics supports research groups in the development of new cellular drugs. Using living cells for therapy is a promising alternative when classical treatment methods fail in the fight against the most severe diseases. In addition to stem cell transplantation, therapies using genetically modified cells have now also been approved in Europe as so-called advanced therapy medicinal products.

Chronic fatigue syndrome (CFS) is a heavy burden. The "EXTINCT post COVID" project is investigating the effectiveness of apheresis therapy and is seeking participants for a study. The Corona pandemic seems to have been overcome; mandatory masks and other restrictions have largely been abolished. However, about one in ten people continue to suffer the consequences of a Corona infection for longer: persistent fatigue, exhaustion, heart problems, poor concentration and shortness of breath.

In a multicentre phase 3 trial, researchers at the MHH have demonstrated the efficacy and safety of the drug Bulevirtide, which prevents HD viruses from entering the liver. Infection with hepatitis D virus (HDV) causes the most severe form of chronic, viral hepatitis disease. About ten to 20 million people worldwide are affected.

The bacterium Haemophilus influenzae type b (Hib) can cause severe meningitis in young children. Our researchers now have a way to make the Hib vaccine cheaply and more easily. The bacterium Haemophilus influenzae type b (Hib) can cause severe diseases such as meningitis and blood poisoning in young children.

A clinical trial will investigate the drug's efficacy in dementia patients. A common feature of many neurodegenerative diseases are pathological protein deposits in the brain. These protein aggregates cause nerve cells to die and, as a result, entire brain areas to shrink, which manifests itself in affected individuals as progressive dementia.

Research team of the MHH and the Cluster of Excellence RESIST clarify cell mechanism. The result is the basis for new therapies. How do human cells defend themselves against adenoviruses? The team of RESIST Professor Dr. Sabrina Schreiner from the Institute of Virology at the Hannover Medical School (MHH) has come a good deal closer to answering this question.

Feature combination of Siglec-16 and polysialic acid increases survival in patients with glioblastoma Glioblastomas are malignant brain tumours with a poor prognosis because they usually do not respond to common cancer therapies. One reason for this is that the tumour cells have developed mechanisms to evade immune defence.

In a large study led by the MHH neurology department, researchers investigated the cognition of patients with the rare disease NMOSD. It was found that about 20 percent of those affected have limited cognitive abilities. People with the rare neuromyelitis optica spectrum disease (NMOSD) have severe physical and psychological impairments.

International study with participation of MHH Professor Arndt Vogel shows improved overall survival with immunotherapy New cases of bile duct cancer, also known as biliary tumours, are increasing worldwide. The chances of cure are considered poor. The standard therapy for advanced bile duct cancer has so far been based on chemotherapy with the therapeutic agents gemcitabine and cisplatin; treatment with the body's own immune defence system has been researched for years for this type of cancer.

Researchers at the Clinic for Rehabilitation and Sports Medicine provide concrete measurement data for the first time How high is the training effect for users of electric bicycles, also called pedelecs? What positive effects on health can be expected? Scientists from the Department of Rehabilitation and Sports Medicine at Hannover Medical School (MHH) investigated these questions in a study that lasted almost three years.

In pulmonary arterial hypertension (PAH), the small vessels in the lungs become increasingly narrow and obstruct the transport of blood to the lungs. A new drug can stop this change and possibly even reverse it. Pulmonary arterial hypertension (PAH) is a special form of pulmonary hypertension. It occurs because the small arteries in the lungs narrow as a result of progressive changes in the blood vessels.

How can people be prevented from being affected again after a stroke? In order to find new therapeutic approaches for prevention, the international CRESCENDO consortium led by the MHH is conducting research at the molecular level. In Germany, 270,000 people suffer a stroke every year. This can result in severe disabilities: Paralysis, speech disorders and problems walking.

New test provides information on the progression of precancerous lesions Preliminary stages of cervical cancer occur mainly in women between 25 and 35 years of age. The main risk factor for developing cervical cancer is the human papillomavirus (HPV). Surgery is the treatment of choice. However, such an operation is problematic for pregnant women: since a piece of the uterus is removed, the risk of bleeding and premature birth increases because the cervix shortens and is no longer stable enough.

In our inner ear, there are two different types of sensory cells that are responsible for hearing. An MHH research team has now identified the molecular switch for the formation of these inner and outer hair cells and thus found an important building block for the treatment of hearing loss. The inner and outer hair cells develop before birth from a common type of precursor cells.

Cardiovascular and pulmonary diseases are closely linked. Researchers at the MHH now want to demonstrate the molecular mechanisms and investigate the influence of age-related changes in the heart, lungs and immune system. Cardiovascular diseases and diseases of the lower respiratory tract are among the most common causes of death, especially in older people.

An MHH research team is investigating mechanisms for the development of pre-eclampsia. This could lead to a new therapeutic approach for the disease. Pre-eclampsia - formerly also called pregnancy poisoning or gestosis - is one of the most common diseases of expectant mothers during pregnancy. It occurs in about five percent of all pregnancies and can even be fatal if left untreated.

Centre for Clinical Studies (ZKS) brings findings from science into practical application Hannover Medical School (MHH) is one of Germany's leading institutions in vaccine research. Before new vaccines are launched on the market, they have to undergo extensive clinical testing. The requirements for a clinical trial are high, the bureaucratic effort for planning and implementation is immense.

MHH psychiatry coordinates largest German study to improve depression treatment Using biomarkers to find individual diagnostic and therapeutic paths - what already works in oncology is also to become possible in psychiatry. Under the leadership of Professor Dr Helge Frieling, Vice Head of the Department of Psychiatry, Social Psychiatry and Psychotherapy at the Hannover Medical School (MHH), a national research network is now being launched that aims to tailor the treatment of depression more closely to the individual patient than before.

Drug prevents entry of HD viruses into liver cell Status: October 27, 2022 Infection with hepatits D virus (HDV) causes the most severe form of chronic, viral hepatitis disease. Around ten to 20 million people worldwide are affected. There is no cure for the disease, and in the end the only treatment option is often a liver transplant.