EMBL researchers and colleagues have analysed the effects of 144 antibiotics on our most common gut microbes. Their study substantially improves our understanding of antibiotics’ effects. It also suggests a new approach to mitigating the adverse effects of antibiotics therapy on the gut microbiome through the combination of antibiotics with a second drug.
EMBL researchers and colleagues have analysed the effects of 144 antibiotics on our most common gut microbes. Their study substantially improves our understanding of antibiotics' effects. It also suggests a new approach to mitigating the adverse effects of antibiotics therapy on the gut microbiome through the combination of antibiotics with a second drug. Antibiotics help us to treat bacterial infections and save millions of lives each year. But they can also harm the helpful microbes residing in our gut, weakening one of our body's first lines of defence against pathogens and compromising the multiple beneficial effects our microbiota has for our health. Common side effects of this collateral damage of antibiotics are gastrointestinal problems and recurrent Clostridioides difficile infections. They also include long-term health problems, such as the development of allergic, metabolic, immunological or inflammatory diseases.
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