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Researchers from the University of Bonn are using an innovative method to watch immune receptors go about their business Immune cells are capable of detecting infections just like a sniffer dog, using special sensors known as Toll-like receptors, or TLRs for short. But what signals activate TLRs, and what is the relationship between the scale and nature of this activation and the substance being detected? In a recent study, researchers from the University of Bonn and the University Hospital Bonn (UKB) used an innovative method to answer these questions.

Head and neck cancers are among the ten most common cancers worldwide. Head and neck tumors account for about three to five percent of all cancers, with squamous cell carcinomas being the predominant form. They occur in areas such as the oral cavity, pharynx and larynx. An international team of researchers led by Sara Wickström has now developed a new technique that allows the properties of cancer cells and their surrounding tissue to be analyzed in detail at the single-cell level.

Researchers from the University of Bonn have trained an AI process to predict potential active ingredients with special properties. Therefore, they derived a chemical language model - a kind of ChatGPT for molecules. Following a training phase, the AI was able to exactly reproduce the chemical structures of compounds with known dual-target activity that may be particularly effective medications.

Spatial proteomics provides therapeutic approach for patients with toxic epidermal necrolysis A global team of researchers at the Max Planck Institute of Biochemistry has made a groundbreaking discovery that saves the lives of patients suffering from toxic epidermal necrolysis. This rare but often fatal reaction to common medications causes widespread detachment of the skin.

In Germany, around 17,000 people are diagnosed with gastric cancer every year. The disease is one of the leading causes of tumour-related deaths. This is due to late diagnosis and the rapid spread of tumour cells throughout the body. In two international clinical trials, a team of scientists involving the University of Leipzig Medical Center have investigated a drug that can prolong patients' survival.

Researchers at the University of Leipzig Medical Center have deciphered a new mechanism that plays a central role in the development of diabetic kidney disease. Their study focuses on a coagulation protein. It can be detected in urine samples from patients in the early stages of the disease and can be used as a diagnostic marker.

A new highly effective thrombosis inhibitor is in sight: Würzburg scientists present promising inhibitor EMA601 for efficient prevention and treatment of arterial thrombosis and inflammatory reactions without increased bleeding risk. An unhealthy lifestyle, diseases or injuries, genetic predisposition, and increased coagulation tendency can promote the formation of thrombi in blood vessels.

In a first, a Bochum-based team has produced a substance capable of sending cancer cells into ferroptosis, that is a specific form of cell death. This could pave the way for the development of new drugs. Conventional cancer drugs work by triggering apoptosis, that is programmed cell death, in tumor cells.

A substance derived from the plant Ardisia crenata works in a different way than existing drugs. And in doing so, it is highly effective. Pulmonary hypertension is a very serious disease that leads to heart failure and death in many patients. Searching for new treatment options, a team headed by Professor Daniela Wenzel and Alexander Seidinger from the Department of Systems Physiology at Ruhr University Bochum, Germany, tested the plant substance FR900359 - referred to as FR by the researchers.

G protein-coupled receptors (GPCRs) are found throughout the human body and are involved in many complex signalling pathways. Despite their importance in many biological processes, the central mechanism of G protein-coupling and the associated signal transmission is not yet understood. A team of researchers from Leipzig University has succeeded in understanding the mechanism of signal transmission through an adrenaline-binding receptor at the atomic level.

A low vitamin B6 level has negative effects on brain performance. A research team from Würzburg University Medicine has now found a way to delay the degradation of the vitamin. Vitamin B6 is important for brain metabolism. Accordingly, in various mental illnesses, a low vitamin B6 level is associated with impaired memory and learning abilities, with a depressive mood, and even with genuine depression.

Research team at the University of Freiburg identifies new membrane protein Sd-Amt1 A team led by Freiburg biochemist Susana Andrade has characterised a new membrane protein that allows microorganisms to repurpose ammonium transporters (Amts) as receptors. Ammonium transporters clearly distinguish between ammonium, potassium and water.

What mucins can do in medicine They are in our eyes, on our tongues, and in our stomachs: Protective layers of mucus, a slime consisting primarily of mucins. These are molecules which bind water to form a natural lubricant. Researchers at the Technical University of Munich (TUM) use them to develop coatings for contact lenses and intubation tubes, healing plasters for use on the tongue and intestines, and much more.

Researchers at Freie Universität Berlin and Charité - Universitätsmedizin Berlin "defanging" bacteria, rendering them harmless In most cases, antibiotics are a reliable form of protection against bacterial infections. They have saved billions of human lives since their introduction. This protection, however, is threatened by bacteria's resistance to classical antibiotics and by their aggressive pathogenicity.

Twenty years ago, a drug candidate was rejected due to its side effects. Researchers have now figured out how to potentially make a successor molecule more selective. An increasing number of bacteria have become resistant to many commonly used antibiotics. Researchers from Bochum have discovered a fresh opportunity for a potential active molecule whose predecessor was rejected: By studying its interaction with the bacterial target protein very precisely in three dimensions, they identified a previously undetected point of attack that could be targeted by this compound.

A newly identified compound prevents a cellular enzyme from cleaving the virus particle. As a result, the virus can no longer infect cells. At present, there is no specific active substance against hepatitis E. As the disease kills 70,000 people every year, researchers are actively searching for one.

Antibacterial substance from staphylococci discovered with new mechanism of action against natural competitors Many bacteria produce substances to gain an advantage over competitors in their highly competitive natural environment. Researchers at the University Hospital Bonn (UKB), the University of Bonn and the German Center for Infection Research (DZIF) have discovered a new so-called lantibiotic, namely epilancin A37.

Newly discovered mechanism could significantly improve cancer immunotherapies Tumors actively prevent the formation of immune responses by so-called cytotoxic T cells, which are essential in combating cancer. Researchers at the Technical University of Munich (TUM) and the Ludwig-Maximilians-Universität München (LMU) Hospital have now uncovered for the first time how this exactly happens.

CAR T cell therapy has proven effective in treating various haematological cancers. However, not all patients respond equally well to treatment. In a recent clinical study, researchers from the University of Leipzig Medical Center and the Fraunhofer Institute for Cell Therapy and Immunology identified several biomarkers that are associated with the response to CAR T cell therapy in multiple myeloma, a malignant tumour disease in the bone marrow.

An international research team has investigated the biosynthesis of psilocybin, the main ingredient of hallucinogenic mushrooms. They gained new insights into the structure and reaction mechanism of the enzyme PsiM. It plays a key role in the production of psilocybin. The results of the study were published in the journal "Nature Communications".