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News from the Lab (news.myScience.ch)

  • News from the Lab’ is a selection of scientific works that are significant or interesting for a broad readership. 
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Pharmacology



Results 1 - 20 of 66.
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Health - Pharmacology - 14.10.2021
Help for the weakened heart
Help for the weakened heart
MHH research team demonstrates how inflammatory cells improve the function of diseased heart muscle cells Heart failure or cardiac insufficiency is one of the most common causes of death in Germany and is caused by heart attacks, high blood pressure or heart valve defects. The heart is then no longer able to pump a sufficient amount of blood through the body and supply organs, muscles or other tissues with enough oxygen and nutrients.

Health - Pharmacology - 13.10.2021
Tackling the collateral damage from antibiotics
Tackling the collateral damage from antibiotics
Antibiotics help us to treat bacterial infections and save millions of lives each year. But they can also harm the helpful microbes residing in our gut, weakening one of our body's first lines of defence against pathogens and compromising the multiple beneficial effects our microbiota has for our health.

Health - Pharmacology - 13.09.2021
Insights into the cellular and molecular changes in male infertility
Insights into the cellular and molecular changes in male infertility
"You can't see the wood for the trees" is a phrase which we certainly don't associate immediately with the medical examination and analysis of testicles. But in a certain way it applies here, too: testicles consist of many different types of cells, and up to now this complex quality prevented these types from being isolated and then analysed.

Pharmacology - Health - 02.09.2021
Bypassing side effects: Nanocontainers transport active ingredients directly to their target
Bypassing side effects: Nanocontainers transport active ingredients directly to their target
Using nanoparticles, a Jena research team implemented the targeted transport of an active ingredient into liver tissue. Using nanoparticles, a Jena research team implemented the targeted transport of an active ingredient into liver tissue. The particles were functionalized with a dye that is specifically absorbed by liver cells, and they carried an inhibitor of the signal protein PI3Kinase ? , which contributes to the development of liver failure in sepsis.

Health - Pharmacology - 18.08.2021
New approach identifies T cells in Covid-19 patients
New approach identifies T cells in Covid-19 patients
Immune cell profile reveals appearance, number and activity level against SARS-CoV-2 T cells play a decisive role in fighting the coronavirus and preventing infected individuals from becoming seriously ill. They identify and fight the virus directly within the infected cells. A team of researchers working in Munich have produced a precise profile of the T cells that respond to SARS-CoV-2 and described them at various stages of the illness.

Pharmacology - Sport - 06.08.2021
Doping Drug Detectable in the Body Weeks After Ingestion
The findings come as the result of anti-doping research at Freie Universität Berlin funded by the World Anti-Doping Agency (WADA) No 153/2021 from Aug 06, 2021 According to a study spearheaded by Freie Universität Berlin, the anabolic androgenic steroid dehydrochloromethyltestosterone (DHCMT) is detectable in the body for several weeks after administration.

Health - Pharmacology - 30.07.2021
Combination vaccines against Covid-19 tested
Immune response stronger than after two doses of AstraZeneca vaccine People under the age of 60 who initially received a vaccine from AstraZeneca should be given an mRNA vaccine at their second appointment. This is recommended by the German Standing Committee on Vaccination. However, up until now, there were no data available to indicate to what extent the human organism would react to such a combined vaccination and start to form antibodies.

Health - Pharmacology - 30.07.2021
Mix-and-match vaccines against Covid-19 tested
Immune response stronger than after two doses of AstraZeneca vaccine People under the age of 60 who initially received a vaccine from AstraZeneca should be given an mRNA vaccine at their second appointment. This is recommended by the German Standing Committee on Vaccination. However, up until now, there were no data available to indicate to what extent the human organism would react to such a mix-and-match vaccination and start to form antibodies.

Health - Pharmacology - 25.05.2021
Focus on life-threatening fungal infections
Focus on life-threatening fungal infections
Collaborative Research Center granted DFG funding for a further four years. The German Research Foundation (DFG) will fund the Collaborative Research Center/Transregio (CRC/TR) "FungiNet" for four more years with approximately ten million Euro. In the only CRC studying human pathogenic fungi, scientists in Jena and Würzburg will investigate infection processes and novel therapeutic options.

Pharmacology - Chemistry - 10.05.2021
New, Promising Ways of Fighting Viruses
New, Promising Ways of Fighting Viruses
A research team including scientists from Freie Universität Berlin is investigating novel antiviral drugs that can also inhibit the spread of coronaviruses No 086/2021 from May 10, 2021 Researchers from the Institute of Pharmacy at Freie Universität Berlin, in collaboration with researchers at Katholieke Universiteit Leuven, have discovered a new process for developing antiviral agents for drugs.

Health - Pharmacology - 06.04.2021
Small cell lung cancer: scientists identify two new approaches for therapy
Iron-dependent cell death ferroptosis and cell death by oxidative stress can be activated in small cell lung cancer, and induced by two drugs / publication in 'Nature Communications' Using samples of small cell lung tumours, a research team led by biologist Dr Silvia von Karstedt has discovered two new ways to induce tumour cell death.

Chemistry - Pharmacology - 25.03.2021
Chemists achieve breakthrough in the production of three-dimensional molecular structures
Chemists achieve breakthrough in the production of three-dimensional molecular structures
A major goal of organic and medicinal chemistry in recent decades has been the rapid synthesis of three-dimensional molecules for the development of new drugs. These drug candidates exhibit a variety of improved properties compared to predominantly flat molecular structures, which are reflected in clinical trials by higher efficacy and success rates.

Pharmacology - Health - 24.03.2021
Hypnosis is beneficial for surgical patients
Hypnosis is beneficial for surgical patients
Meta-analysis reveals: Hypnosis relieves pain, reduces mental distress and promotes recovery after surgery Hypnosis relieves pain, reduces mental distress and promotes recovery after surgical interventions - this has been shown in a meta-analysis recently published in Clinical Psychology Review. By evaluating 50 individual studies with over 4000 patients, scientists from Jena and Leipzig examined the efficacy of hypnosis in the context of surgical interventions.

Pharmacology - Life Sciences - 05.03.2021
A new model can predict the evolution of antibiotic resistance in bacteria
An international research team has developed a model that predicts growth rates and resistance mechanisms of common bacterial mutants at different drug doses / Publication in 'Nature Ecology & Evolution' A team of scientists from the University of Cologne (Germany) and the University of Uppsala (Sweden) has created a model that can describe and predict the evolution of antibiotic resistance in bacteria.

Health - Pharmacology - 12.02.2021
Medication-based starvation of cancer cells
Medication-based starvation of cancer cells
Findings on cancer medication reveal protein regulation mechanism Immunomodulatory drugs, including the Contergan derivatives lenalidomide and pomalidomide have significantly improved the therapy of hematologic malignancies such as multiple myeloma. Researchers at the Technical University of Munich (TUM) have now further decoded the mode of action in this class of medications.

Health - Pharmacology - 12.02.2021
Synthetic -mini- receptors block atherosclerosis
New synthetic peptides could attenuate atherosclerosis Atherosclerosis, a lipid-triggered chronic inflammatory disease of our arteries, is the main cause of strokes and heart attacks. An international team of researchers led by the Technical University of Munich (TUM) and the LMU University Hospital has developed novel synthetic peptides that can help to prevent atherosclerosis in vitro, that is in the test tube, as well as in animal models.

Health - Pharmacology - 27.01.2021
New promising target for diabetes treatment
Blocking the receptor "inceptor" could protect insulin-producing beta cells One hundred years after the discovery of insulin and fifty years after that of the insulin receptor, researchers have now discovered a novel - and druggable - insulin inhibitory receptor, named inceptor. This could open up new possibilities for the treatment of diabetes: The blocking of inceptor function leads to an increased sensitisation of the insulin signaling pathway in pancreatic beta cells.

Health - Pharmacology - 11.01.2021
Polycystic kidney disease: Study explores diet as a key factor in kidney disease
Polycystic kidney disease: Study explores diet as a key factor in kidney disease
A new clinical study at the University of Cologne and Cologne University Hospital is investigating whether a ketogenic diet has a positive effect on patients with polycystic kidney disease / The trial is funded by the American PKD Foundation (polycystic kidney disease) A team of researchers at the University of Cologne is launching a study on the effects of ketogenic dietary regimens in patients affected by hereditary polycystic kidney disease (ADPKD).

Health - Pharmacology - 17.12.2020
Breathing rate predicts therapeutic benefits for heart patients
Discovering a forgotten biosignal Conditions causing arrhythmia are among the most common cardiac conditions. A study headed by Prof. Georg Schmidt of the Technical University of Munich (TUM) has demonstrated for the first time that the nocturnal respiratory rate can help with an important prediction: It is an indicator of whether a defibrillator will help to extend the life of patients with arrhythmia.

Health - Pharmacology - 05.12.2020
How Covid-19 Testing Can Become More Efficient
How Covid-19 Testing Can Become More Efficient
With the help of so-called pooling procedures, samples from different people can be combined into a pool and tested for Covid-19 collectively in a single test kit. An interdisciplinary team of mathematicians, computer scientists and medical doctors from the Junge Akademie, the Technische Universität Braunschweig, the Universität Stuttgart and the company Arctoris has developed a decision support tool that calculates which method is most effective in identifying all Covid-19 patients in a positive sample pool.
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