Professor Lachmann with a bottle of sodium chloride infusion solution. Professor Lachmann aims to revolutionise the safety of drugs given parenterally by injection. Copyright: Karin Kaiser / MHH
Professor Lachmann with a bottle of sodium chloride infusion solution. Professor Lachmann aims to revolutionise the safety of drugs given parenterally by injection. Copyright: Karin Kaiser / MHH - MHH professor receives "ERC Proof of Concept Grant" to revolutionise drug safety / Novel immune cells to benefit millions of people Medicines that are injected must be continuously tested for impurities as part of their production and release, as these can cause fever or even blood poisoning. Until now, this has mostly been done using animal tests, animal products or the so-called monocyte activation test (MAT). But the use of animal tests and products must be avoided - also because they do not adequately reflect human physiology in some cases and because the European authorities will no longer accept them from 2026. The MAT based on donated blood cells better reflects human physiology, but is not sufficiently accepted by the industry as blood donations are scarce and blood cells vary greatly. So far, the only alternative is artificial cells derived from cancer tissue, but these cannot detect all impurities.
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