Team from the University of Münster presents computer-aided method / Counteracting subjective bias in studies on the production of new chemical compounds
The team led by Prof Frank Glorius transferred all’approved active pharmaceutical ingredients into a digital code. Chemists often develop and optimise new chemical reactions using so-called model systems, i.e. simple, easily accessible substrates. They then use up to around 100 other substrates as examples to show that the reaction works. This demonstration of versatile applicability is called "scope" in technical jargon. However, a subjective selection of substrates often results in a distorted picture of the range of applications of the newly developed reaction. It is often unclear whether it can be used to synthesise a desired product.
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