Schematic drawing: The liposome is carrying molecules of active ingredient (orange) and dye (blue). Image: M. Leitner/UKJ
Schematic drawing: The liposome is carrying molecules of active ingredient ( orange ) and dye ( blue ). Image: M. Leitner/UKJ - Using nanoparticles, a Jena research team implemented the targeted transport of an active ingredient into liver tissue. The particles were functionalized with a dye that is specifically absorbed by liver cells, and they carried an inhibitor of the signal protein PI3Kinase ', which contributes to the development of liver failure in sepsis. However, outside liver cells, the signal protein is involved in pathogen reduction; this desired immune activity remained unhindered. This novel approach to the treatment of septic liver failure has recently been published in EMBO Molecular Medicine. The signal protein PI3Kinase - is an all-rounder: It plays a role, for example, in blood clotting, it is involved in blood pressure regulation and metabolic processes, and it pilots immune cells to the site of infection and controls their fight against pathogens. Its role in sepsis is, however, rather inglorious.
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