Freie Universität Berlin Contributes to Research Project Backed by the World Anti-Doping Agency
No 193/2019 from Jun 25, 2019
According to a study conducted by a group of international researchers, including experts from Freie Universität Berlin, a chemical extract from spinach plants can be used to boost the performance of competitive athletes. The World Anti-Doping Agency (WADA) commissioned researchers to study the effects of ecdysterone, a kind of phytosteroid, on strength training. Their findings indicate that the substance greatly affects muscle cells. Among the researchers who suggested that the WADA add ecdysterone to the list of prohibited substances was Maria Parr, a professor of pharmaceutical chemistry at Freie Universität. Professor Parr specializes in pharmaceutical analytics and metabolism. Phytosteroids belong to the chemical class of substances known as sterols and can be found naturally in plants. They are chemical derivatives of cholesterol. In addition to Maria Parr from Freie Universität, other contributing researchers included Prof. Patrick Diel from the German Sport University Cologne, Prof. Francesco Botrè from the anti-doping lab in Rome, and Dr. Catrin Goebel from the anti-doping lab in Sydney.
In the double-blind study, one group of athletes received a controlled amount of the spinach extract, while another received a placebo, without either knowing which they were taking. After the ten-week test period, the athletes who actually took ecdysterone showed a significant increase in maximum muscle strength.
Ecdysterone is the main component in spinach extracts. The research team was able to show that the substance affects estrogen receptor beta. Many dietary supplements on the market contain the spinach chemical. Maria Parr noted that ecdysterone had already been dubbed "the Russian secret" for enhancing athletic performance a few years ago. Earlier in vitro and animal experiments showed that it had a very strong effect on muscle cells, even stronger than anabolic androgenic steroids, such as metandienone, which is prohibited in sports. Profess Parr further explained that the low dose of two pills per day, which they used for some of the participants in the experiment, would amount to anywhere between 250 grams and four kilograms of spinach per day, depending on the variety. A person would have to eat that amount every day over the course of four weeks in order to consume the same amount as one of these low-dose athletes. In order to consume the same level as those administered high doses, a person would have to eat between one to 16 kilograms of spinach, she explained.