Loops in our DNA

The DNA is labeled with fluorescent dyes and tethered to a glass surface on both ends to observe it in a microscope. The videos show how the Protein Smc5/6 extrudes DNA loops in real-time. In the left video, it can be seen that the Smc5/6 protein ( red ) binds to the DNA ( cyan ) and then starts to extrude the loop. MPI of Biophysics/ Biswajit Pradhan - The entire genetic information of living organisms is stored in the form of DNA in the tiny nuclei of their cells. How a protein called Smc5/6 controls the safe packaging of genetic material in chromosomes by extruding loops from the DNA has now been revealed by an international team of researchers from Eugene Kim's group at the Max Planck Institute of Biophysics in Frankfurt am Main and from the Karolinska Institute in Sweden. Reproduction and evolution of life - from humans to bacteria - are based on preserving, adapting and passing on genetic information. The genetic material is stored in the form of DNA in almost every single cell of an organism, or more precisely in the nuclei.