Silence for thought

Human neuronal networks, mapped from different parts of the cerebral cortex. Connectomic comparison to mouse revealed massively expanded interneuron-to-interneuron networks in human. Loomba, Helmstaedter, MPI for Brain Research;  Loomba et al. Science 2022 - Scientists map prominent differences in the neural circuits of mice, monkeys, and human The analysis of the human brain is a central goal of neuroscience. However, for methodological reasons, research has largely focused on model organisms, in particular the mouse. Now, neuroscientists gained novel insights on human neural circuitry using tissue obtained from neurosurgical interventions. Three-dimensional electron microscope data revealed a novel expanded network of interneurons in humans compared to mouse.