Why aortic aneurysms occur at the vascular arch or in the abdominal section

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Hematoxylin and eosin staining of cross-sections of the mouse abdominal aorta: -
Hematoxylin and eosin staining of cross-sections of the mouse abdominal aorta: - Left: Image of a healthy mouse aorta. Right: image of an aortic aneurysm. Scale bar: 200 micrometers. Photo: Daniela Wenzel Download all images in original size All rights reserved!
The usual sites where vascular bulges form are predestined for this from the outset, even in healthy people. This is shown by a study conducted by the Bochum and Bonn medical departments. If a vascular aneurysm bursts in the aorta, it poses an acute danger to life. These so-called aortic aneurysms typically form in the same places on the large blood vessel: either on the upper arch or in the abdominal cavity. "We wanted to know why it is always these sites of all places - what distinguishes them from others?" explains Daniela Wenzel, Head of the Department of Systems Physiology at Ruhr University Bochum. Investigations into the gene activity of the innermost vascular layer showed that even in healthy mice there are abnormalities at precisely these sites. ...
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