Future process aims at preserving the advantages of PEGylation for the use in nanomedicine while avoiding recognition of the new PEG structures by the immune system
Since the first PEGylated drug was developed in the 1980s, the so-called PEGylation has become a standard procedure in the pharmaceutical sciences. The technique involves concealing active biopharmaceuticals under a kind of "cloak of invisibility" by means of conjugation with the polymer polyethylene glycol (PEG). Consequently, they are not subjected to rapid degradation or undesirable attack by the immune system. The mRNA vaccines designed to protect against infection with the coronavirus are, for example, PEGylated. ...
