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Results 21 - 40 of 172.


Health - Pharmacology - 06.11.2023
Improving the efficacy of cancer immunotherapy with modified CAR-T cells
Improving the efficacy of cancer immunotherapy with modified CAR-T cells
Freiburg researchers achieved a significantly improved anti-tumour efficacy of CAR-T cells in a preclinical model CAR-T cell therapy is a last hope for many patients with blood, bone marrow or lymph gland cancer when other treatments such as chemotherapy are unsuccessful. A limiting factor of this otherwise very effective and safe therapy is that the cells used in the process quickly reach a state of exhaustion.

Health - Pharmacology - 26.10.2023
ERC Synergy Grant for Immunotherapy of Liver Metastases
ERC Synergy Grant for Immunotherapy of Liver Metastases
Four distinguished immunologists have been awarded one of the most generously funded research grants from the EU: the ERC Synergy Grant. They aim to explore new avenues for immunotherapy of liver metastases. A significant proportion of cancer patients do not succumb to the initial tumor but rather to the resulting metastases.

Life Sciences - Pharmacology - 29.09.2023
Combating Multidrug-Resistant Bacteria through High-Resolution Structural Imaging
Combating Multidrug-Resistant Bacteria through High-Resolution Structural Imaging
A European research team led by the Department of Chemistry at Universität Hamburg presents a study showing high-resolution structures of 17 distinct antibiotic ribosomal compounds. The knowledge could pave the way for the development of new antibiotics to combat multidrug-resistant bacteria. The results were published in the journal Nature Structural & Molecular Biology.

Health - Pharmacology - 19.09.2023
Testing for long Covid: Eye exam as a new approach - TUM
Testing for long Covid: Eye exam as a new approach - TUM
Blood vessels in the eye altered with persistent coronavirus symptoms New approach to testing for long Covid A standardized eye examination might reveal in future whether people are suffering from long Covid syndrome or post-Covid. A team at the Technical University of Munich (TUM) was able to demonstrate a clear connection between the disease and certain changes to the blood vessels in the eye.

Health - Pharmacology - 06.09.2023
Ablation ensures survival benefits in terminal heart failure
In contrast to treatment with medication alone, patients benefit from additional catheter ablation, a new study shows. Heart specialists from the Heart and Diabetes Center NRW (HDZ NRW), Bad Oeynhausen, have demonstrated for the first time worldwide in a monocentric, open study that patients suffering from severe heart failure (cardiac insufficiency) in combination with symptomatic atrial fibrillation benefit more from catheter ablation in combination with guideline-compliant drug therapy than from drug therapy alone.

Health - Pharmacology - 05.09.2023
New approach in the treatment of non-alcoholic fatty liver disease (NAFLD)
The prebiotic resistant starch could play an important role in the treatment of non-alcoholic fatty liver disease (NAFLD) in the future. Initial indications suggest that a specially adapted diet with resistant starch not only positively influences the intestinal microbiome but also leads to an alleviation of the disease.

Health - Pharmacology - 28.08.2023
High mortality from heart failure despite mechanical cardiovascular support
High mortality from heart failure despite mechanical cardiovascular support
Worldwide, there is a proliferation in the use of mechanical active cardiovascular support. The hope is to use these assist devices to improve survival after the most severe form of acute heart failure, cardiogenic shock. A recent clinical study, led by heart specialist Prof. Holger Thiele, has shown that these devices do not reduce mortality after cardiogenic shock within 30 days.

Health - Pharmacology - 25.08.2023
Adrenocortical carcinoma: No mitotane for low risk of recurrence
Adrenocortical carcinoma: No mitotane for low risk of recurrence
After the complete tumour resection, not all patients with an adrenocortical carcinoma require the previous standard therapy Mitotane. Professors Martin Fassnacht and Massimo Terzolo show this in a clinical trial. In 2017, the teams of Massimo Terzolo and Martin Fassnacht published a study in the New England Journal of Medicine that provided evidence for the efficacy of Mitotane in the prevention of recurrence in adrenocortical carcinoma.

Health - Pharmacology - 21.08.2023
Timing is key
Whether you have a sports injury, repetitive strain injury or pain in the knee, cortisone preparations are often used to treat acute inflammations. Chronic inflammatory diseases such as asthma, diabetes and chronic inflammatory bowel diseases are also treated with drugs containing cortisone or derived drugs.

Health - Pharmacology - 17.08.2023
Anti-obesity drug improves associative learning in people with obesity
Obesity leads to altered energy metabolism and reduced insulin sensitivity of cells. The so-called "anti-obesity drugs" are increasingly used to treat obesity and have caused tremendous interest, especially in the USA. Researchers at the Max Planck Institute for Metabolism Research in Cologne, Germany, have now shown in people with obesity that reduced insulin sensitivity affects learning of sensory associations.

Health - Pharmacology - 08.08.2023
Inhalation drug prevents severe pneumonia
Inhalation drug prevents severe pneumonia
Sugar molecule accurately delivers RNA drug to target cells Overly active immune cells are often behind lung damage in diseases such as Covid-19. Researchers at the Technical University of Munich (TUM) have developed an RNA agent for a lung spray that slows the activity of these cells, known as macrophages.

Innovation - Pharmacology - 31.07.2023
Pills from the 3D printer
Pills from the 3D printer
Pills could soon be produced in shapes that resemble design objects. And this would not be just an aesthetic gimmick, but would serve to release active medical ingredients in the body in a controlled manner. A group of computer scientists from the Max Planck Institute for Informatics in Saarbrücken and the University of California at Davis have developed a process that uses a combination of computation and 3D printing to produce tablets that dissolve in liquids over a specified period of time.

Pharmacology - Health - 21.07.2023
Cause of sleep disturbance in cardiac disease identified
Cause of sleep disturbance in cardiac disease identified
Ganglia play previously unrecognized role in diseases Around one third of people with heart disease suffer from sleep problems. In a paper published in the journal Science, a team at the Technical University of Munich (TUM) shows that heart diseases affect the production of the sleep hormone melatonin in the pineal gland.

Health - Pharmacology - 14.07.2023
Link between oropharyngeal cancer and sexual behaviour
Link between oropharyngeal cancer and sexual behaviour
The development of head and neck cancer is increasingly linked to HPV infection, which is a sexually transmitted disease.

Health - Pharmacology - 13.07.2023
CytoSorb : widely used, but no proven benefit
CytoSorb : widely used, but no proven benefit
Many hospitals use the adsorber to purify the blood of seriously ill patients in order to trap inflammatory substances and prevent the life-threatening cytokine storm. Many hospitals use the adsorber to purify the blood of seriously ill patients in order to trap inflammatory substances and prevent the life-threatening cytokine storm.

Health - Pharmacology - 11.07.2023
New marker for cancer cell motility
New marker for cancer cell motility
Physics of Cancer finds first potential application in oncology - More accurate prognosis of how breast tumours spread Researchers led by Leipzig University have found a ground-breaking application in oncology for the scientific field of Physics of Cancer. This is a milestone for the new research field, proving its clinical relevance for the first time.

Health - Pharmacology - 10.07.2023
Putting innovative research on the road to the clinic
Putting innovative research on the road to the clinic
The ATMP-GMPDU development unit at the Institute for Cell Therapeutics supports research groups in the development of new cellular drugs. Using living cells for therapy is a promising alternative when classical treatment methods fail in the fight against the most severe diseases. In addition to stem cell transplantation, therapies using genetically modified cells have now also been approved in Europe as so-called advanced therapy medicinal products.

Health - Pharmacology - 04.07.2023
Does blood purification help against severe fatigue in post-COVID?
Does blood purification help against severe fatigue in post-COVID?
Chronic fatigue syndrome (CFS) is a heavy burden. The "EXTINCT post COVID" project is investigating the effectiveness of apheresis therapy and is seeking participants for a study. The Corona pandemic seems to have been overcome; mandatory masks and other restrictions have largely been abolished. However, about one in ten people continue to suffer the consequences of a Corona infection for longer: persistent fatigue, exhaustion, heart problems, poor concentration and shortness of breath.

Health - Pharmacology - 22.06.2023
New weapon against hepatitis D
New weapon against hepatitis D
In a multicentre phase 3 trial, researchers at the MHH have demonstrated the efficacy and safety of the drug Bulevirtide, which prevents HD viruses from entering the liver. Infection with hepatitis D virus (HDV) causes the most severe form of chronic, viral hepatitis disease. About ten to 20 million people worldwide are affected.

Health - Pharmacology - 21.06.2023
Single hepatitis E mutation renders sofosbuvir therapy ineffective
Single hepatitis E mutation renders sofosbuvir therapy ineffective
A single mutation stands in the way of a drug's effectiveness. Understanding it helps find new therapeutic approaches. So far, there are no specific drugs to treat the hepatitis E virus. Doctors only have the broad-spectrum antiviral drug ribavirin at their disposal, which is often associated with severe side effects.