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Life Sciences
Results 141 - 160 of 1119.
Boosting Cold Shock Protein in the Brain Protects Mice against Neurodegenerative Disease
Researchers from the University of Cambridge and Freie Universität Berlin publish findings in "EMBO Molecular Medicine" Scientists in Cambridge and Berlin - including biochemist Professor Florian Heyd - have made an important step in understanding and treating neurodegeneration by using a form of gene therapy to increase levels of cold shock protein in the brains of mice, protecting them against the potentially devastating impact of prion disease, which can cause rare forms of dementia.
Researchers from the University of Cambridge and Freie Universität Berlin publish findings in "EMBO Molecular Medicine" Scientists in Cambridge and Berlin - including biochemist Professor Florian Heyd - have made an important step in understanding and treating neurodegeneration by using a form of gene therapy to increase levels of cold shock protein in the brains of mice, protecting them against the potentially devastating impact of prion disease, which can cause rare forms of dementia.
Making rare cell types visible: Researchers are developing a new method
The human body contains more than 30 trillion cells. Until recently, the sheer number of cells in the organism meant that approaches to understanding human diseases and developmental processes based on the analysis of single cells were a futuristic vision. The development of new sequencing methods is currently revolutionising our understanding of cellular heterogeneity.
The human body contains more than 30 trillion cells. Until recently, the sheer number of cells in the organism meant that approaches to understanding human diseases and developmental processes based on the analysis of single cells were a futuristic vision. The development of new sequencing methods is currently revolutionising our understanding of cellular heterogeneity.
New Type of Friction Discovered in Ligand-Protein Systems
A team from the University of Freiburg and the Max Planck Institute of Biophysics in Frankfurt-am-Main identifies anisotropic friction An interdisciplinary research team of the Institutes of Physical Chemistry and Physics of the University of Freiburg and the Max Planck Institute of Biophysics in Frankfurt-am-Main has discovered a new, direction-dependent friction in proteins called anisotropic friction.
A team from the University of Freiburg and the Max Planck Institute of Biophysics in Frankfurt-am-Main identifies anisotropic friction An interdisciplinary research team of the Institutes of Physical Chemistry and Physics of the University of Freiburg and the Max Planck Institute of Biophysics in Frankfurt-am-Main has discovered a new, direction-dependent friction in proteins called anisotropic friction.
How plants adapt to nitrogen deficiency
Researchers at the University of Bonn discover gene variants in wheat and barley that improve nitrogen utilization Nitrogen as a fertilizer can increase yields. However, too much nitrogen can also have negative effects, such as groundwater pollution, high energy consumption in fertilizer production and the generation of climate-relevant gases.
Researchers at the University of Bonn discover gene variants in wheat and barley that improve nitrogen utilization Nitrogen as a fertilizer can increase yields. However, too much nitrogen can also have negative effects, such as groundwater pollution, high energy consumption in fertilizer production and the generation of climate-relevant gases.
Intestinal bacteria trigger postoperative complications
Previously, it was believed that a germ-free environment was the most critical factor in preventing postoperative infections. However, a recent study by Mercedes Gomez de Agüero's team from the Max Planck Research Group for Systems Immunology in Würzburg, Germany, in collaboration with the University Hospital of Bern, Switzerland, has revealed that the source of the danger is apparently entirely different: the patients' intestines.
Previously, it was believed that a germ-free environment was the most critical factor in preventing postoperative infections. However, a recent study by Mercedes Gomez de Agüero's team from the Max Planck Research Group for Systems Immunology in Würzburg, Germany, in collaboration with the University Hospital of Bern, Switzerland, has revealed that the source of the danger is apparently entirely different: the patients' intestines.
Dieting: brain amplifies signal of hunger synapses
Many people who have dieted are familiar with the yo-yo effect: after the diet, the kilos are quickly put back on. Researchers from the Max Planck Institute for Metabolism Research and Harvard Medical School have now shown in mice that communication in the brain changes during a diet: The nerve cells that mediate the feeling of hunger receive stronger signals, so that the mice eat significantly more after the diet and gain weight more quickly.
Many people who have dieted are familiar with the yo-yo effect: after the diet, the kilos are quickly put back on. Researchers from the Max Planck Institute for Metabolism Research and Harvard Medical School have now shown in mice that communication in the brain changes during a diet: The nerve cells that mediate the feeling of hunger receive stronger signals, so that the mice eat significantly more after the diet and gain weight more quickly.
Attack from the gut
Intestinal bacteria are often the trigger of complications after surgery. This is shown in a new study by research teams from Würzburg and Bern. A solution to this problem could come from the liver. Nearly 16 million operations were performed on inpatients in German hospitals in 2021. In Switzerland, the figure is around 1.1 million.
Intestinal bacteria are often the trigger of complications after surgery. This is shown in a new study by research teams from Würzburg and Bern. A solution to this problem could come from the liver. Nearly 16 million operations were performed on inpatients in German hospitals in 2021. In Switzerland, the figure is around 1.1 million.
Many genes are involved in ’resurrection’
Researchers from the Universities of Bonn and Michigan analyze the genome of a drought-tolerant plant Some plants can survive months without water, only to turn green again after a brief downpour. A recent study by the Universities of Bonn and Michigan shows that this is not due to a "miracle gene." Rather, this ability is a consequence of a whole network of genes, almost all of which are also present in more vulnerable varieties.
Researchers from the Universities of Bonn and Michigan analyze the genome of a drought-tolerant plant Some plants can survive months without water, only to turn green again after a brief downpour. A recent study by the Universities of Bonn and Michigan shows that this is not due to a "miracle gene." Rather, this ability is a consequence of a whole network of genes, almost all of which are also present in more vulnerable varieties.
Beethoven’s genome
Scientists have sequenced the composer's genome using five genetically matching hair locks The study shows Beethoven was predisposed to liver disease, and infected with Hepatitis B, which - combined with his alcohol consumption - may have contributed to his death. Furthermore, DNA from modern relatives points to an extramarital 'event' in Beethoven's paternal line.
Scientists have sequenced the composer's genome using five genetically matching hair locks The study shows Beethoven was predisposed to liver disease, and infected with Hepatitis B, which - combined with his alcohol consumption - may have contributed to his death. Furthermore, DNA from modern relatives points to an extramarital 'event' in Beethoven's paternal line.
Beethoven’s genome offers clues to composer’s health and family history
International team of scientists deciphers renowned composer's genome from locks of hair Ludwig van Beethoven's genome has been sequenced for the first time by an international team of scientists with the participation of the University of Bonn using five genetically matching locks of the well-known composer's hair.
International team of scientists deciphers renowned composer's genome from locks of hair Ludwig van Beethoven's genome has been sequenced for the first time by an international team of scientists with the participation of the University of Bonn using five genetically matching locks of the well-known composer's hair.
Cellular waste removal differs according to cell type
Study by the University of Bonn identifies different types of so-called lysosomes "Miniature shredders" are at work in each cell, disassembling and recycling cell components that are defective or no longer required. The exact structure of these shredders differs from cell type to cell type, a study by the University of Bonn now shows.
Study by the University of Bonn identifies different types of so-called lysosomes "Miniature shredders" are at work in each cell, disassembling and recycling cell components that are defective or no longer required. The exact structure of these shredders differs from cell type to cell type, a study by the University of Bonn now shows.
Neurology team researches mechanisms of repeated strokes
How can people be prevented from being affected again after a stroke? In order to find new therapeutic approaches for prevention, the international CRESCENDO consortium led by the MHH is conducting research at the molecular level. In Germany, 270,000 people suffer a stroke every year. This can result in severe disabilities: Paralysis, speech disorders and problems walking.
How can people be prevented from being affected again after a stroke? In order to find new therapeutic approaches for prevention, the international CRESCENDO consortium led by the MHH is conducting research at the molecular level. In Germany, 270,000 people suffer a stroke every year. This can result in severe disabilities: Paralysis, speech disorders and problems walking.
Animal intelligence: Bees navigate with memory maps
According to a new study, bees have a map-like landscape memory and are able to fly from any location to a place indicated in their tail dance. The research team's findings, which have now been published, provide a completely new assessment of the information content of the bees' so-called tail dance.
According to a new study, bees have a map-like landscape memory and are able to fly from any location to a place indicated in their tail dance. The research team's findings, which have now been published, provide a completely new assessment of the information content of the bees' so-called tail dance.
Watching atherosclerosis as it develops
Researchers at the University of Tübingen have developed a new method to better study atheroscle-rosis in mice. The non-invasive imaging method helps to better understand and treat narrowing of blood vessels, a cause of heart attacks and strokes. The new approach may also significantly reduce the number of animals used in experiments compared to previous methods.
Researchers at the University of Tübingen have developed a new method to better study atheroscle-rosis in mice. The non-invasive imaging method helps to better understand and treat narrowing of blood vessels, a cause of heart attacks and strokes. The new approach may also significantly reduce the number of animals used in experiments compared to previous methods.
How fishermen benefit from reversing evolution of cod
News from Intense fishing and overexploitation have led to evolutionary changes in fish stocks like cod, reducing both their productivity and value on the market. These changes can be reversed by more sustainable and far-sighted fisheries management.
News from Intense fishing and overexploitation have led to evolutionary changes in fish stocks like cod, reducing both their productivity and value on the market. These changes can be reversed by more sustainable and far-sighted fisheries management.
Air pollution impairs successful mating of flies
High levels of ozone destroy the chemical mating signal of the insects and may thus contribute to global insect decline A research team at the Max Planck Institute for Chemical Ecology in Jena, Germany, demonstrates that increased levels of ozone resulting from anthropogenic air pollution can degrade insect sex pheromones, which are crucial mating signals, and thus prevent successful reproduction.
High levels of ozone destroy the chemical mating signal of the insects and may thus contribute to global insect decline A research team at the Max Planck Institute for Chemical Ecology in Jena, Germany, demonstrates that increased levels of ozone resulting from anthropogenic air pollution can degrade insect sex pheromones, which are crucial mating signals, and thus prevent successful reproduction.
Immune cells have a backup mechanism
If the TBK1 enzyme is mutated, susceptibility to viral infections increases - unless it is missing The enzyme TBK1 is an important component of the innate immune system that plays a critical role in the defense against viruses. Upon mutation-induced loss of TBK1 function, patients show an increased susceptibility to viral infections.
If the TBK1 enzyme is mutated, susceptibility to viral infections increases - unless it is missing The enzyme TBK1 is an important component of the innate immune system that plays a critical role in the defense against viruses. Upon mutation-induced loss of TBK1 function, patients show an increased susceptibility to viral infections.
French-German Team Refutes Standard Model of Electroporation
Technology developed at University of Freiburg enables experimental test Strong electric fields can be used to create pores in biomembranes. The method is known as electroporation. Inducing such defects in membranes in a targeted manner is an important technique in medicine and biotechnology, but also in the treatment of foodstuffs.
Technology developed at University of Freiburg enables experimental test Strong electric fields can be used to create pores in biomembranes. The method is known as electroporation. Inducing such defects in membranes in a targeted manner is an important technique in medicine and biotechnology, but also in the treatment of foodstuffs.
New stem cell model developed for research into a life-threatening malformation of the newborn lung
Study investigates cause and new therapeutic approach for congenital diaphragmatic hernia Congenital diaphragmatic hernia is one of the deadliest birth defects. To better understand and treat this condition in the future, an international team of researchers involving Leipzig University Hospital designed a new cell model in the laboratory and tested a drug therapy on it.
Study investigates cause and new therapeutic approach for congenital diaphragmatic hernia Congenital diaphragmatic hernia is one of the deadliest birth defects. To better understand and treat this condition in the future, an international team of researchers involving Leipzig University Hospital designed a new cell model in the laboratory and tested a drug therapy on it.
Major advance in super-resolution fluorescence microscopy
Pushing the MINFLUX technique to higher spatial and temporal precision allows protein dynamics to be observed under physiological conditions Scientists led by Nobel Laureate Stefan Hell at the Max Planck Institute for Medical Research in Heidelberg have developed a super-resolution microscope with a spatio-temporal precision of one nanometer per millisecond.
Pushing the MINFLUX technique to higher spatial and temporal precision allows protein dynamics to be observed under physiological conditions Scientists led by Nobel Laureate Stefan Hell at the Max Planck Institute for Medical Research in Heidelberg have developed a super-resolution microscope with a spatio-temporal precision of one nanometer per millisecond.