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News from the Lab (news.myScience.ch)

  • News from the Lab’ is a selection of scientific works that are significant or interesting for a broad readership. 
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Life Sciences - Health - 09.11.2015
Possible Reasons Found for Failure of Alzheimer's Treatment
Possible Reasons Found for Failure of Alzheimer’s Treatment
Agglutinated proteins in the brain, known as amyloid-? plaques, are a key characteristic of Alzheimer's. One treatment option uses special antibodies to break down these plaques. This approach yielded good results in the animal model, but for reasons that are not yet clear, it has so far been unsuccessful in patient studies.

Life Sciences - Health - 04.11.2015
Protein Repairs Nerve Cell Damage
Protein Repairs Nerve Cell Damage
In laboratory experiments on the basic mechanisms that cause Alzheimer's dementia, an international research team led by Heidelberg neurobiologist Ulrike Müller and a team of French scientists have succeeded in largely "repairing" the nerve cell damage typical in this disease. The researchers took a closer look at a key protein in Alzheimer's pathogenisis, APP, and one of its cleavage products APPs'.

Health - Life Sciences - 30.10.2015
Novel high-throughput approach for the analysis of cancer genes
Novel high-throughput approach for the analysis of cancer genes
An international team of scientists, led by Prof. Roland Rad at the University Hospital Klinikum rechts der Isar of Technical University of Munich (TUM), has developed a multiplexed screening approach together with colleagues of the Wellcome Trust Sanger Institute. The method can be used to mutate simultaneously many different genes in adult mice.

Health - Life Sciences - 29.10.2015
New state-of-the-art compact X-ray source
New state-of-the-art compact X-ray source
For some years now it has been possible to generate high-brilliance X-rays using ring-shaped particle accelerators (synchrotron sources). However, such installations are several hundred meters in diameter and cost billions of euros. The world's first mini synchrotron was inaugurated today at Technical University of Munich (TUM).

Health - Life Sciences - 27.10.2015
Lifestyle Change Could Reduce Risk of Alzheimer’s
Changes in lifestyle could reduce the risk of developing Alzheimer's disease. That was the conclusion of a study conducted by researchers of Heidelberg University's Network Aging Research (NAR), who examined the data from two independent epidemiological studies. Carriers of the ApoE4 genetic risk factor for Alzheimer's may be able to reduce their increased risk of cognitive decline by reducing their cholesterol level, especially if they also suffer from cardiovascular disease.

Life Sciences - Health - 22.10.2015
Alzheimer's disease: Plaques impair memory formation during sleep
Alzheimer’s disease: Plaques impair memory formation during sleep
Alzheimer's patients frequently suffer from sleep disorders, mostly even before they become forgetful. Furthermore, it is known that sleep plays a very important role in memory formation. Researchers from the Technical University of Munich (TUM) have now been able to show for the first time how the pathological changes in the brain act on the information-storing processes during sleep.

Life Sciences - Health - 12.10.2015
New field of application for versatile helper
New field of application for versatile helper
In Alzheimer's disease proteins clump together to long fibrils causing the death of nerve cells. Small heat shock proteins can counteract this effect. Scientists, therefore, hope to deploy them as agents in the treatment of neurodegenerative diseases. Using the example of a small heat shock protein, researchers at the Technical University of Munich (TUM) and the Helmholtz Zentrum München have now uncovered how the protein interacts with other proteins.

Health - Life Sciences - 12.10.2015
Jamming the signal
LMU researchers have developed a short peptide that inhibits the activation of a signal pathway in monocytes that enables monocytes to adhere stick to endothelial cells and penetrate sites of acute inflammation. The image depicts the binding of the SKY peptide to CCL5 (green), which inhibits docking of HNP1 and thus prevents the formation of the HNP1-CCL5 heteromer.

Health - Chemistry - 01.10.2015
Cell marker enables prognosis about the course of infections
Cell marker enables prognosis about the course of infections
When a pathogen invades the body, specific cells in the human immune system are ready to take immediate action in order to destroy it. The molecular characteristics of these killer cells were unknown until recently. Now, for the first time, a team from the Technical University of Munich (TUM) has managed to create a molecular profile of the protective cells.

Health - Life Sciences - 23.09.2015
25 million euros for multiple sclerosis research
25 million euros for multiple sclerosis research
As one of the central fields of medical research at the Technical University of Munich (TUM), neuroscience is to gain a new research center for multiple sclerosis (MS). In Germany alone, some 200,000 people are affected by this as yet incurable disease, the cause of which remains unknown. Researchers at the TUM Klinikum rechts der Isar will now focus on MS and link clinical aspects of the disease with basic research.

Health - Life Sciences - 23.09.2015
Pancreatic cancer: TUM researchers develop a new therapy concept
Pancreatic cancer: TUM researchers develop a new therapy concept
Pancreatic cancer is one of the most aggressive forms of cancer and one of the most difficult to treat. Its high resistance to treatment is a major problem, particularly in the advanced stages. Researchers at Klinikum rechts der Isar University Hospital of the Technical University of Munich (TUM) have joined forces with a team from Stanford University to investigate a conceptually new approach to therapy which primarily takes epigenetic mechanisms into consideration.

Life Sciences - Health - 22.09.2015
Promising results with inhibitors of amyloid formation
When proteins change their structure and clump together, formation of amyloid fibrils and plaques may occur. Such "misfolding" and "protein aggregation" processes damage cells and cause diseases such as Alzheimer's and type 2 diabetes. A team of scientists from the Technical University of Munich (TUM) headed by Professor Aphrodite Kapurniotu have now developed molecules that suppress protein aggregation and could pave the way for new treatments to combat Alzheimer's, type 2 diabetes and other cell-degenerative diseases.

Life Sciences - Health - 22.09.2015
Ringing in the ears and chronic pain enter by the same gate
Ringing in the ears and chronic pain enter by the same gate
Tinnitus and chronic pain have more in common than their ability to afflict millions with the very real experience of "phantom" sensations. Scientists noted similarities between the two disorders more than thirty years ago. Now advances in brain imaging and associated techniques have enabled researchers to begin homing in on their structural and functional bases, revealing what appears to be a central gatekeeping system implicated in both chronic pain and tinnitus.

Life Sciences - Health - 31.08.2015
Overlooked for 30 years: a new kid on the block
A team led by Christian Haass has identified a novel peptide that plays a role in Alzheimer's disease: The previously overlooked eta-amyloid interferes with neuronal function and may antogonize beta-amyloid - a finding that has implications for ongoing clinical trials. Alzheimer's disease is associated with the appearance of characteristic neurotoxic protein aggregates in various regions in the brain.

Health - Physics - 12.08.2015
Attosecond Electron Catapult
Attosecond Electron Catapult
A team of physicists and chemists has studied the interaction of light with tiny glass particles The relationship between strong laser pulses and glass nanoparticles is a special one - one that could influence medical methods, as scientists from Rostock, Munich, and Berlin have discovered.

Life Sciences - Health - 04.08.2015
Simply Turn Off a Virus
Scientists at Freie Universität Develop a New Method for the Detailed Investigation of Functional RNA Elements Scientists at Freie Universität Berlin and the University of Strasbourg (France) have developed a new method for studying the function of ribonucleic acid (RNA) that provides more detailed results, is more cost-effective, as well as easier to work with than previous methods.

Life Sciences - Health - 03.08.2015
Stroke: News about platelets
Stroke: News about platelets
Platelets play a key role in strokes: They can even drive nerve cells in the brain into a kind of suicide mode, as scientists from the University of Würzburg now report in the journal "Blood". A stroke typically develops as follows: A blood vessel supplying the brain with vital oxygen and nutrients is blocked by a blood clot, resulting in nerve cell death.

Life Sciences - Health - 09.12.2014
Invasion to the inside
In order to multiply, influenza viruses are dependent on cells of a human or animal body. They board those cells, for example all along the lung surface, and their genetic material migrates into the nucleus, where it is replicated. As a result, new viruses come to life. A team led by scientists from the Cells-in-Motion Cluster of Excellence (CiM), University of Münster, has now, for the first time, succeeded in visualizing structures of the viral genome inside of human cells by light microscopy.

Life Sciences - Health - 27.04.2012
Spin-off Eliminates Animal Testing
Chemical, medication and cosmetic manufacturers are obligated to test their products for possible health risks using appropriate means, as stipulated by various European guidelines. Animal testing is frequently used to determine the dangers of such products to the human eye. Aside from ethical reasons, arguments against this form of testing include high costs, delays due to approval procedures, and concerns whether the results from animal testing can be extrapolated safely to human beings.

Life Sciences - Health - 07.01.2011
The Import Business of Cellular Power Plants Freiburg Scientists Reveal Newly Discovered Communication Path in Cells
Scientists from Freiburg's two Excellence Institutions Centre for Biological Signalling Studies (BIOSS) and Spemann Graduate School of Biology and Medicine (SGBM) have discovered a new signaling path in cells: a mechanism which enables the transport of proteins into mitochondria to be adjusted depending on the current metabolic state of the cell.
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