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Chemists and pharmaceutical scientists at Heidelberg University develop an innovative process for producing these biologically active compounds A cutting-edge chemical process is the first to make it possible to quickly and easily produce modified peptides with boronic acids. It was developed by scientists from the Institute of Organic Chemistry and the Institute of Pharmacy and Molecular Biotechnology at Heidelberg University.

Further action needed according to a University of Bonn study on child and adolescent nutrition A high-sugar diet is seen as a risk factor for obesity and chronic illness. University of Bonn researchers have analyzed data on sugar intake among children and adolescents in a long-term study, finding that intake has been declining steadily since 2010-but is still above the level recommended by the World Health Organization (WHO).

A new combination of single infrared light measurement and machine learning can be used to detect metabolic disorders and high blood pressure Some common diseases could be easier and quicker to diagnose in future. A team from the Max Planck Institute of Quantum Optics, the Ludwig Maximilian University of Munich and the Helmholtz Zentrum München has demonstrated in a representative study that infrared light measurements of blood plasma when combined with machine learning can be used to detect various metabolic disorders such as type-2 diabetes and high blood pressure.

Memory loss, confusion, speech problems - Alzheimer's disease is the most common cause of dementia, affecting about 35 million people worldwide, and the number is growing. The protein amyloid beta, which occurs naturally in the brain, plays a central role in the disease: It accumulates in patients in insoluble clumps that form plaques between neurons in the brain, damaging them.

Prerequisite for protective effects of fasting is an increase in the concentration of the endogenous substance spermidine in the organism / international study involving the team of Stephan Sigrist from Freie Universität According to the results of an international study involving the Freie Universität Berlin, fasting can prolong life and increase the health span.

The protective effects of fasting depend on an increase in the concentration of spermidine, according to an international study involving a team led by Professor Stephan Sigrist from Freie Universität Berlin According to the findings of an international study, fasting can extend people's lifespan and increase overall health.

Mast cells trap and use living neutrophils during allergic reactions Known for their role in allergic reactions, mast cells have long been recognised as key players in our immune system. When they encounter allergens, they release chemicals that trigger typical allergy symptoms such as tissue swelling and inflammation.

Known for their role in allergic reactions, mast cells have long been recognised as key players in our immune system. When they encounter allergens, they release chemicals that trigger typical allergy symptoms such as tissue swelling and inflammation. Now, researchers at the Max Planck Institute of Immunobiology and Epigenetics in Freiburg and the University of Münster have discovered a hidden talent of mast cells: they can capture and use another type of immune cell called neutrophils.

Immune cells in the brain form bridges to nerve cells and protect against neurodegenerative diseases When nerve cells in the brain die, diseases such as Alzheimer's and Parkinson's develop. To protect these cells, there are immune cells in the brain known as microglia. A study has now shown that microglia form tiny tubes, so-called -tunnelling nanotubes-, and thus connect directly to the nerve cells.

In a collaborative project between the Faculty of Veterinary Medicine and the Interdisciplinary Centre for Bioinformatics (IZBI) at Leipzig University, changes in gene expression in sebaceous glands have been spatially mapped for the first time. The study documents at high resolution changes in gene expression in the course of sebum synthesis and identifies new candidates for the modulation of sebum production.

The liver has a remarkable ability to regenerate. This property is crucial for maintaining organ function and recovery after injury or surgery. Scientists from the University of Leipzig Medical Center, the Max Planck Institute for Evolutionary Anthropology, TU Dresden and ETH Zurich have used clinical samples to investigate how cell types in the liver change before and after regeneration.

People trust medical advice less if they suspect that an artificial intelligence is involved in its creation. This is the key finding of a study by psychologists from the University of Würzburg. People used to ask Dr. Google if they wanted to know whether their symptoms indicate a mild stomach upset or terminal cancer; today, they are increasingly turning to ChatGPT.

Bonn researchers confirm three other genes for increased risk in addition to the known TLR7 gene Whether or not a person becomes seriously ill with COVID-19 depends, among other things, on genetic factors. With this in mind, researchers from the University Hospital Bonn (UKB) and the University of Bonn, in cooperation with other research teams from Germany, the Netherlands, Spain and Italy, investigated a particularly large group of affected individuals.

Freiburg researchers develop new formal description of internal world models, thereby enabling interdisciplinary research A team of scientists led by Ilka Diester , Professor of Optophysiology and spokesperson of the BrainLinks-BrainTools research centre at the University of Freiburg, has developed a formal description of internal world models and published it in the journal Neuron .

A team at the Helmholtz Centre for Infection Research in Würzburg, Germany, led by RNA expert Chase Beisel, has developed a new technology for the precise detection of RNA using DNA-cutting Cas12 nucleases. CRISPR-Cas systems, defense systems in bacteria, have become a plentiful source of technologies for molecular diagnostics.

Researchers investigate the strong interaction of cholera toxin with a key ganglioside on the surface of intestinal cells Cholera infections caused by Vibrio cholerae bacteria can be life-threatening and the trigger is the cholera toxin produced by the bacteria. It binds to the surface of intestinal cells - more precisely, to certain "sugar lipids" (GM1 gangliosides, GM1) on the cell surfaces.

There are currently around 1.8 million people living with dementia in Germany. Due to increased life expectancy, the proportion will continue to grow: based on data from the Federal Statistical Office, experts expect up to two million cases in 2033. For the first time, an intervention study was carried out to prevent mental decline in older GP patients.

The usual sites where vascular bulges form are predestined for this from the outset, even in healthy people. This is shown by a study conducted by the Bochum and Bonn medical departments. If a vascular aneurysm bursts in the aorta, it poses an acute danger to life. These so-called aortic aneurysms typically form in the same places on the large blood vessel: either on the upper arch or in the abdominal cavity.

New research by the University Hospital Bonn (UKB) in cooperation with the University of Bonn has shown for the first time that certain early changes in patients with age-related macular degeneration (AMD) can lead to a measurable local loss of vision. This discovery could help to improve the treatment and monitoring of this eye disease in older patients, which otherwise slowly leads to central blindness, and to test new therapies.

Freiburg-Prague research collaboration achieves scientific breakthrough in understanding cell division.