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News from the Lab (news.myScience.ch)

  • News from the Lab’ is a selection of scientific works that are significant or interesting for a broad readership. 
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Pharmacology



Results 1 - 20 of 95.
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Life Sciences - Pharmacology - 03.06.2022
Deep Learning helps improve gene therapies and antiviral drugs
Team led by bioinformatician Rolf Backofen develops algorithm to identify anti-CRISPR protein The nuclease Cas13b associated with the CRISPR gene scissors, which is an enzyme that degrades nucleic acids, has the potential to be used in the future in hereditary diseases to switch off unwanted genes. In the fight against infections, this nuclease is also being researched as an antiviral agent, as Cas13b can specifically intervene in the genetic material of viruses and render them harmless.

Health - Pharmacology - 01.06.2022
Misperceptions about doctor's trust in Covid-19 vaccines influence vaccination rate
Misperceptions about doctor’s trust in Covid-19 vaccines influence vaccination rate
Informing people about the strong positive consensus among doctors persistently leads to increases in Covid-19 vaccinations How to increase vaccination rates by autumn, without any compulsion is shown by an international research team including the Max Planck Institute for Tax Law and Public Finance.

Health - Pharmacology - 31.05.2022
Drug combination triples survival time with blood cancer
Drug combination triples survival time with blood cancer
MHH involved in international study on acute myeloid leukaemia (AML) Acute myeloid leukaemia (AML) is a malignant disease in which the precursor cells of the haematopoietic system multiply uncontrollably. This form of blood cancer is caused by genetic changes in the bone marrow that occur in the course of life.

Health - Pharmacology - 31.05.2022
Vaccination strategy can be optimised with computer model
HU research team simulates COVID-19 outbreaks with virtual agents A new model for simulating COVID-19 outbreaks helps to develop the right strategy for herd immunity for every municipality and city - even in the event of vaccine shortages. For, even after two years of the pandemic, countries, municipalities and cities are still experiencing severe COVID-19 outbreaks.

Pharmacology - Health - 05.05.2022
Small changes - but essential! How peptides are recognised in receptors
Small changes - but essential! How peptides are recognised in receptors
Researchers discover molecular mechanisms of signal recognition of the neuropeptide system The human body consists of trillions of cells that constantly communicate with each other. A central role in this communication process is played by receptor proteins on the cell surface. Since they often serve as drug targets, they have been the subject of intensive research.

Health - Pharmacology - 28.04.2022
Vaccination campaign messages often prove ineffective
Vaccination campaign messages often prove ineffective
Conventional vaccination campaign messages often miss their targets. A study in eight European countries shows that information on the benefits of vaccines can even reduce the willingness to get immunized. The researchers also looked into the factors that influenced the impact of messages, including low health literacy.

Health - Pharmacology - 26.04.2022
Liver fibrosis: the fatal signalling pathway
MHH research team clarifies how liver inflammation and scarring of liver tissue are connected At least five million people in Germany suffer from liver disease. Fibrosis, the pathological proliferation of connective tissue, plays an important role in many complications of chronic liver problems. Activated hepatic stellate cells (HSCs) are massively involved in this tissue remodelling.

Health - Pharmacology - 13.04.2022
COVID-19 therapy: better in combination than alone
How a well-known drug can become a game changer - A joint press release by Charité, the MDC and FU Berlin There is a steadily growing arsenal of drugs for COVID-19. Researchers from Charité - Universitätsmedizin Berlin, the Max Delbrück Center for Molecular Medicine (MDC) and Freie Universität (FU) Berlin have studied the mechanisms of action of antiviral and anti-inflammatory drugs.

Health - Pharmacology - 05.04.2022
Researcher wants to stop harmful effect of chemotherapy on heart muscle
EU funds research project to elucidate pathological cardiac remodelling caused by cancer drugs with around 2.5 million euros 04. Heart failure is one of the most common causes of death worldwide. The disease, known in medicine as cardiac insufficiency, affects about four million people in Germany.

Pharmacology - Health - 25.03.2022
Bioactive substance inhibits important receptor
Bioactive substance inhibits important receptor
Study shows how bioactive substance inhibits important receptor Study shows how bioactive substance inhibits important receptor Results from the University of Bonn raise hope for new drugs against cancer and brain diseases The A2A receptor regulates how vigorously the innate immune system attacks diseased cells.

Health - Pharmacology - 22.03.2022
The right diet can safeguard against acute kidney injury
A research team led by Professor Dr Roman-Ulrich Müller has established that four out of six different nutritional strategies prevent acute kidney injury in the mouse model. Furthermore, the team identified a potential mechanism protecting the organs in their interdisciplinary, translational study. This is the first step towards transferring the results from bench to bedside.

Life Sciences - Pharmacology - 21.03.2022
Brain stimulation shows beneficial effects for motor deficits following stroke
Brain stimulation shows beneficial effects for motor deficits following stroke
This promising non-invasive method can be used for rehabilitation, provided that an individualised approach is developed Persistent paralysis and coordination problems are among the most common consequences of a stroke. Scientists at the Max Planck Institute for Human Cognitive and Brain Sciences in Leipzig, the University Medical Center Halle, and the Charité -Universitätsmedizin in Berlin have discovered that brain stimulation helps.

Health - Pharmacology - 18.03.2022
No benefit from hemoadsorption in endocarditis surgery
No benefit from hemoadsorption in endocarditis surgery
In a controlled multicenter trial, a research team from Jena University Hospital investigated the benefit of hemoadsorption during cardiac surgery, aimed at reducing blood levels of inflammatory mediators, on clinical outcome. The study, now presented in Circulation, shows that hemoadsorption reduced plasma cytokines during surgery, but did not affect any of the clinically relevant outcomes.

Pharmacology - Life Sciences - 10.03.2022
Toolbox for systematic study of receptor regulation
Toolbox for systematic study of receptor regulation
Researchers from Jena and Bonn have developed a cell system to analyze the regulation of G protein-coupled receptors. To prevent overstimulation, these pharmacologically important receptors can be inactivated by specific enzymes inside the cell. That desensitization mechanism is suspected of playing a crucial role for habituation on painkillers or anti-asthmatics.

Life Sciences - Pharmacology - 18.02.2022
Plants Under Anaesthesia
Plants Under Anaesthesia
02/18/2022 The carnivorous Venus flytrap can be anaesthetised with ether. Some surprising parallels to anaesthesia in humans emerge. Medicine has a broad repertoire of anaesthetics at its medication allows patients to better endure painful treatments or even sleep through them. As early as 1842, ether was first used for a dental treatment in New York.

Health - Pharmacology - 17.02.2022
New organ-on-chip system enables precise monitoring of 3D tumour tissue outside the body
New organ-on-chip system enables precise monitoring of 3D tumour tissue outside the body
3D tissue structures on the chip act as organs in miniature A research team around Andreas Weltin, Dr. Jochen Kieninger and Johannes Dornhof from the Department of Microsystems Engineering (IMTEK) at the University of Freiburg has developed a system that, among other things, makes it possible to study the development of tumour cells outside the human body in a three-dimensional environment.

Health - Pharmacology - 14.02.2022
Mechanism of Cerebral Venous Thrombosis Discovered
Mechanism of Cerebral Venous Thrombosis Discovered
02/14/2022 Cerebral venous thrombosis is a rare, often severe disease that has been brought to public attention by the Covid 19 pandemic. Researchers have now succeeded for the first time in deciphering a molecular cause of this disease. Cerebral venous thrombosis is a rare form of cerebral circulatory disorder that, unlike classic stroke, more often affects younger people.

Health - Pharmacology - 11.02.2022
Chemotherapy or not? Physicists study gene expression tests
Following surgery, patients with breast cancer are faced with the question of whether additional chemotherapy is necessary and really effective. It is important that these women do not receive too much treatment - but not too little treatment either. Physicists from Leipzig University modelled the gene expression tests and examined their usefulness on the basis of these models.

Health - Pharmacology - 03.02.2022
'Inflaming' cold tumors
’Inflaming’ cold tumors
Pancreatic carcinoma is a tumor with an extremely poor prognosis for which effective treatments have not yet been found. In a preclinical animal model with mice, a team of researchers has now discovered a way of making pancreatic tumors treatable with immunotherapy methods using a targeted combination of two cancer drugs.

Health - Pharmacology - 01.02.2022
Covid-19: Three exposures needed for broad immunity
Covid-19: Three exposures needed for broad immunity
Number of exposures to viral spike protein crucial for effective antibody response The immune system develops a high-quality antibody response after three encounters with the coronavirus spike protein. These antibodies are also capable of neutralizing Omicron efficiently. This applies to people who are triple-vaccinated, to those having recovered and then received two vaccinations and to double-vaccinated individuals who have experienced a breakthrough infection.
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