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Health - Pharmacology - 14:09

Milestone in pulmonary hypertension therapy
In pulmonary arterial hypertension (PAH), the small vessels in the lungs become increasingly narrow and obstruct the transport of blood to the lungs. A new drug can stop this change and possibly even reverse it. Pulmonary arterial hypertension (PAH) is a special form of pulmonary hypertension. It occurs because the small arteries in the lungs narrow as a result of progressive changes in the blood vessels.

Pharmacology - Health - 14.03.2023

Receptor ’blasting’ visualised
Adhesion GPCRs are a group of G protein-coupled receptors associated with many body functions and diseases. However, they have not yet been sufficiently studied to be used for therapies. Two research groups at the Rudolf Schönheimer Institute at the Faculty of Medicine at Leipzig University have now jointly developed a technology to change this.

Health - Pharmacology - 01.03.2023

Artificial intelligence to help tumor immunology
Researchers want to study the environment of cancer cells in more detail. Federal Ministry of Education and Research funds project with 800,000 euros The success of cancer treatment depends not only on the type of tumor, but also on the surrounding tissue. Tumors influence it to their advantage, promoting the growth of blood vessels or fooling incoming immune cells.

Pharmacology - Health - 19.01.2023

New hope for treatment of rare metabolic disease
Results of a controlled clinical trial with a new drug for the treatment of X-linked adrenoleukodystrophy To date, no pharmacological treatment exists for X-linked adrenoleukodystrophy, a progressive genetic metabolic disease that damages the adrenal glands, the spinal cord and the white matter of the nervous system.

Pharmacology - Life Sciences - 17.01.2023

Paderborn scientist is researching new approaches to combat antibiotic-resistant germs
Dr. Adrian Keller receives Paderborn University Research Award Antibiotics are regularly used in medicine to fight bacterial infections. However, resistant germs to which drugs are unable to respond are now increasingly emerging, especially in hospitals. This is because as bacteria reproduce and further develop, their genetic material - i.e. their DNA - can change to make them resistant to antibiotics.

Health - Pharmacology - 17.01.2023

Endogenous molecule protects from life-threatening complications after stem-cell transplantation
Freiburg researchers find that an antimicrobial molecule modifies T-cell-signalling and thus attenuates overshooting immune reactions Acute Graft-versus-host disease (GvHD) is a life-threatening complication after leukemia treatment with allogeneic stem cell transplantation, i.e. the transplantation of cells from another person.

Health - Pharmacology - 06.01.2023

Simply resolving inflammation through the flick of a switch
Chronic inflammatory processes are the most common causes of a variety of widespread diseases. They play a role in arthritis, asthma, Parkinson's disease and Alzheimer's disease, but also in arteriosclerosis, diabetes and cancer. Drugs that inhibit inflammation are, therefore, among the medicines that are taken most frequently worldwide.

Life Sciences - Pharmacology - 16.12.2022

Starvation Causes Cell Remodeling
New study on "starvation response" by Freie Universität professor of pharmacology published in Science / Joint press release with the Leibniz-Forschungsinstitut für Molekulare Pharmakologie Body cells burn off fat reserves when nutrient supply from food ceases. A team led by Professor Volker Haucke and Dr. Wonyul Jang from the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) has now discovered a previously unknown mechanism for how this "starvation response" is triggered and what can inhibit it.

Life Sciences - Pharmacology - 16.12.2022

When hungry, the cell remodels
Body cells burn fat reserves when the supply of nutrients from food is interrupted. A team led by Volker Haucke of Freie Universität Berlin and the Leibniz Research Institute for Molecular Pharmacology (FMP) and Wonyul Jang of the FMP has now discovered a previously unknown mechanism for how this "starvation metabolism" gets going - and what can inhibit it.

Health - Pharmacology - 12.12.2022

Possible therapeutic approach to fight incurable blood cancer
TUM researchers discover new cell mechanism in multiple myeloma Multiple myeloma (MM) is the second most common type of blood cancer. It attacks the plasma cells in the blood. A team at the Technical University of Munich (TUM) has now discovered a mechanism which provides indications of when and why these cells become aggressive.

Pharmacology - Mathematics - 12.12.2022

New Research Partnership Supports Early-Career Scientists in the Field of Drug Research
The doctoral program PharMetrX of Freie Universität Berlin and the University of Potsdam welcomes the pharmaceutical company Novo Nordisk as new partner PharMetrX - Pharmacometrics & Computational Disease Modelling, an interdisciplinary doctoral program of Freie Universität Berlin and the University of Potsdam, has gained its seventh international partner with the addition of the research-driven pharmaceutical company Novo Nordisk.

Health - Pharmacology - 09.12.2022

Immune booster helps with viral respiratory diseases
Centre for Clinical Studies (ZKS) brings findings from science into practical application Hannover Medical School (MHH) is one of Germany's leading institutions in vaccine research. Before new vaccines are launched on the market, they have to undergo extensive clinical testing. The requirements for a clinical trial are high, the bureaucratic effort for planning and implementation is immense.

Health - Pharmacology - 25.11.2022

Fighting depression with personalised medicine
MHH psychiatry coordinates largest German study to improve depression treatment Using biomarkers to find individual diagnostic and therapeutic paths - what already works in oncology is also to become possible in psychiatry. Under the leadership of Professor Dr Helge Frieling, Vice Head of the Department of Psychiatry, Social Psychiatry and Psychotherapy at the Hannover Medical School (MHH), a national research network is now being launched that aims to tailor the treatment of depression more closely to the individual patient than before.

Health - Pharmacology - 18.11.2022

PETN reduces risk of preterm birth and hypertension in pregnancy
In about one in twenty pregnant women, ultrasound Doppler measurement in mid-pregnancy reveals that the uterus and placenta are not sufficiently supplied with blood. There is then a risk that the baby will not be adequately supplied by the mother's body and will not develop in time. In the worst case, the baby may die in the womb before birth.

Pharmacology - Chemistry - 16.11.2022

Urine reveals our eating habits
We already know that a urine test can establish whether someone has an infection of the urinary tract or has taken illegal drugs. But there are lots more traces to be found in urine - if you know how to read them. Developing and refining techniques to get pointers to a person's eating habits or to harmful substances in their urine is one of the pet projects being pursued by food chemist Prof. Hans-Ulrich Humpf and his working group at the University of Münster.

Health - Pharmacology - 14.11.2022

Attack via byways
Increased cell proliferation is a key feature of diseases such as cancer. A research team from the University of Würzburg and two Leibniz Institutes has now succeeded in indirectly influencing this process. As differently as cancers or autoimmune diseases such as multiple sclerosis, rheumatoid arthritis or psoriasis affect people - they all have one characteristic in common: they are accompanied by increased cell proliferation.

Health - Pharmacology - 24.08.2022

Therapeutic drug renders cancer cell weapon harmless
Already approved drug could pave way to new pharmaceuticals, study by University of Bonn shows Many tumor cells mist themselves with a protective perfume that disables the immune system. But a drug already approved for other purposes can apparently render this weapon harmless. This is shown in a study by the University of Bonn and the University Medical Center Hamburg-Eppendorf, which has now appeared in the Journal for ImmunoTherapy of Cancer.

Pharmacology - Health - 05.07.2022

Molecule boosts fat burning
Study identifies a new signaling molecule that increases the energy consumption of brown fat cells A study led by the University of Bonn and the University Hospital Bonn has identified a molecule - the purine inosine - that boosts fat burning in brown adipocytes. The mechanism was discovered in mice, but probably exists in humans as well: If a transporter for inosine is less active, the mice remain significantly leaner despite a high-fat diet.

Life Sciences - Pharmacology - 03.06.2022

Deep Learning helps improve gene therapies and antiviral drugs
Team led by bioinformatician Rolf Backofen develops algorithm to identify anti-CRISPR protein The nuclease Cas13b associated with the CRISPR gene scissors, which is an enzyme that degrades nucleic acids, has the potential to be used in the future in hereditary diseases to switch off unwanted genes. In the fight against infections, this nuclease is also being researched as an antiviral agent, as Cas13b can specifically intervene in the genetic material of viruses and render them harmless.

Health - Pharmacology - 01.06.2022

Misperceptions about doctor’s trust in Covid-19 vaccines influence vaccination rate
Informing people about the strong positive consensus among doctors persistently leads to increases in Covid-19 vaccinations How to increase vaccination rates by autumn, without any compulsion is shown by an international research team including the Max Planck Institute for Tax Law and Public Finance.