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News from the Lab (news.myScience.ch)

  • News from the Lab’ is a selection of scientific works that are significant or interesting for a broad readership. 
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Pharmacology



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Health - Pharmacology - 25.11.2022
Fighting depression with personalised medicine
Fighting depression with personalised medicine
MHH psychiatry coordinates largest German study to improve depression treatment Using biomarkers to find individual diagnostic and therapeutic paths - what already works in oncology is also to become possible in psychiatry. Under the leadership of Professor Dr Helge Frieling, Vice Head of the Department of Psychiatry, Social Psychiatry and Psychotherapy at the Hannover Medical School (MHH), a national research network is now being launched that aims to tailor the treatment of depression more closely to the individual patient than before.

Health - Pharmacology - 18.11.2022
PETN reduces risk of preterm birth and hypertension in pregnancy
PETN reduces risk of preterm birth and hypertension in pregnancy
In about one in twenty pregnant women, ultrasound Doppler measurement in mid-pregnancy reveals that the uterus and placenta are not sufficiently supplied with blood. There is then a risk that the baby will not be adequately supplied by the mother's body and will not develop in time. In the worst case, the baby may die in the womb before birth.

Pharmacology - Chemistry - 16.11.2022
Urine reveals our eating habits
Urine reveals our eating habits
We already know that a urine test can establish whether someone has an infection of the urinary tract or has taken illegal drugs. But there are lots more traces to be found in urine - if you know how to read them. Developing and refining techniques to get pointers to a person's eating habits or to harmful substances in their urine is one of the pet projects being pursued by food chemist Prof. Hans-Ulrich Humpf and his working group at the University of Münster.

Health - Pharmacology - 14.11.2022
Attack via byways
Attack via byways
Increased cell proliferation is a key feature of diseases such as cancer. A research team from the University of Würzburg and two Leibniz Institutes has now succeeded in indirectly influencing this process. As differently as cancers or autoimmune diseases such as multiple sclerosis, rheumatoid arthritis or psoriasis affect people - they all have one characteristic in common: they are accompanied by increased cell proliferation.

Health - Pharmacology - 24.08.2022
Therapeutic drug renders cancer cell weapon harmless
Therapeutic drug renders cancer cell weapon harmless
Already approved drug could pave way to new pharmaceuticals, study by University of Bonn shows Many tumor cells mist themselves with a protective perfume that disables the immune system. But a drug already approved for other purposes can apparently render this weapon harmless. This is shown in a study by the University of Bonn and the University Medical Center Hamburg-Eppendorf, which has now appeared in the Journal for ImmunoTherapy of Cancer.

Pharmacology - Health - 05.07.2022
Molecule boosts fat burning
Molecule boosts fat burning
Study identifies a new signaling molecule that increases the energy consumption of brown fat cells A study led by the University of Bonn and the University Hospital Bonn has identified a molecule - the purine inosine - that boosts fat burning in brown adipocytes. The mechanism was discovered in mice, but probably exists in humans as well: If a transporter for inosine is less active, the mice remain significantly leaner despite a high-fat diet.

Life Sciences - Pharmacology - 03.06.2022
Deep Learning helps improve gene therapies and antiviral drugs
Team led by bioinformatician Rolf Backofen develops algorithm to identify anti-CRISPR protein The nuclease Cas13b associated with the CRISPR gene scissors, which is an enzyme that degrades nucleic acids, has the potential to be used in the future in hereditary diseases to switch off unwanted genes. In the fight against infections, this nuclease is also being researched as an antiviral agent, as Cas13b can specifically intervene in the genetic material of viruses and render them harmless.

Health - Pharmacology - 01.06.2022
Misperceptions about doctor's trust in Covid-19 vaccines influence vaccination rate
Misperceptions about doctor’s trust in Covid-19 vaccines influence vaccination rate
Informing people about the strong positive consensus among doctors persistently leads to increases in Covid-19 vaccinations How to increase vaccination rates by autumn, without any compulsion is shown by an international research team including the Max Planck Institute for Tax Law and Public Finance.

Health - Pharmacology - 31.05.2022
Drug combination triples survival time with blood cancer
Drug combination triples survival time with blood cancer
MHH involved in international study on acute myeloid leukaemia (AML) Acute myeloid leukaemia (AML) is a malignant disease in which the precursor cells of the haematopoietic system multiply uncontrollably. This form of blood cancer is caused by genetic changes in the bone marrow that occur in the course of life.

Health - Pharmacology - 31.05.2022
Vaccination strategy can be optimised with computer model
HU research team simulates COVID-19 outbreaks with virtual agents A new model for simulating COVID-19 outbreaks helps to develop the right strategy for herd immunity for every municipality and city - even in the event of vaccine shortages. For, even after two years of the pandemic, countries, municipalities and cities are still experiencing severe COVID-19 outbreaks.

Pharmacology - Health - 05.05.2022
Small changes - but essential! How peptides are recognised in receptors
Small changes - but essential! How peptides are recognised in receptors
Researchers discover molecular mechanisms of signal recognition of the neuropeptide system The human body consists of trillions of cells that constantly communicate with each other. A central role in this communication process is played by receptor proteins on the cell surface. Since they often serve as drug targets, they have been the subject of intensive research.

Health - Pharmacology - 28.04.2022
Vaccination campaign messages often prove ineffective
Vaccination campaign messages often prove ineffective
Conventional vaccination campaign messages often miss their targets. A study in eight European countries shows that information on the benefits of vaccines can even reduce the willingness to get immunized. The researchers also looked into the factors that influenced the impact of messages, including low health literacy.

Health - Pharmacology - 26.04.2022
Liver fibrosis: the fatal signalling pathway
MHH research team clarifies how liver inflammation and scarring of liver tissue are connected At least five million people in Germany suffer from liver disease. Fibrosis, the pathological proliferation of connective tissue, plays an important role in many complications of chronic liver problems. Activated hepatic stellate cells (HSCs) are massively involved in this tissue remodelling.

Health - Pharmacology - 13.04.2022
COVID-19 therapy: better in combination than alone
How a well-known drug can become a game changer - A joint press release by Charité, the MDC and FU Berlin There is a steadily growing arsenal of drugs for COVID-19. Researchers from Charité - Universitätsmedizin Berlin, the Max Delbrück Center for Molecular Medicine (MDC) and Freie Universität (FU) Berlin have studied the mechanisms of action of antiviral and anti-inflammatory drugs.

Health - Pharmacology - 05.04.2022
Researcher wants to stop harmful effect of chemotherapy on heart muscle
EU funds research project to elucidate pathological cardiac remodelling caused by cancer drugs with around 2.5 million euros 04. Heart failure is one of the most common causes of death worldwide. The disease, known in medicine as cardiac insufficiency, affects about four million people in Germany.

Pharmacology - Health - 25.03.2022
Bioactive substance inhibits important receptor
Bioactive substance inhibits important receptor
Study shows how bioactive substance inhibits important receptor Study shows how bioactive substance inhibits important receptor Results from the University of Bonn raise hope for new drugs against cancer and brain diseases The A2A receptor regulates how vigorously the innate immune system attacks diseased cells.

Health - Pharmacology - 22.03.2022
The right diet can safeguard against acute kidney injury
A research team led by Professor Dr Roman-Ulrich Müller has established that four out of six different nutritional strategies prevent acute kidney injury in the mouse model. Furthermore, the team identified a potential mechanism protecting the organs in their interdisciplinary, translational study. This is the first step towards transferring the results from bench to bedside.

Life Sciences - Pharmacology - 21.03.2022
Brain stimulation shows beneficial effects for motor deficits following stroke
Brain stimulation shows beneficial effects for motor deficits following stroke
This promising non-invasive method can be used for rehabilitation, provided that an individualised approach is developed Persistent paralysis and coordination problems are among the most common consequences of a stroke. Scientists at the Max Planck Institute for Human Cognitive and Brain Sciences in Leipzig, the University Medical Center Halle, and the Charité -Universitätsmedizin in Berlin have discovered that brain stimulation helps.

Health - Pharmacology - 18.03.2022
No benefit from hemoadsorption in endocarditis surgery
No benefit from hemoadsorption in endocarditis surgery
In a controlled multicenter trial, a research team from Jena University Hospital investigated the benefit of hemoadsorption during cardiac surgery, aimed at reducing blood levels of inflammatory mediators, on clinical outcome. The study, now presented in Circulation, shows that hemoadsorption reduced plasma cytokines during surgery, but did not affect any of the clinically relevant outcomes.

Pharmacology - Life Sciences - 10.03.2022
Toolbox for systematic study of receptor regulation
Toolbox for systematic study of receptor regulation
Researchers from Jena and Bonn have developed a cell system to analyze the regulation of G protein-coupled receptors. To prevent overstimulation, these pharmacologically important receptors can be inactivated by specific enzymes inside the cell. That desensitization mechanism is suspected of playing a crucial role for habituation on painkillers or anti-asthmatics.
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