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News from the Lab (news.myScience.ch)

  • News from the Lab’ is a selection of scientific works that are significant or interesting for a broad readership. 
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Pharmacology



Results 1 - 20 of 56.
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Health - Pharmacology - 06.04.2021
Small cell lung cancer: scientists identify two new approaches for therapy
Iron-dependent cell death ferroptosis and cell death by oxidative stress can be activated in small cell lung cancer, and induced by two drugs / publication in 'Nature Communications' Using samples of small cell lung tumours, a research team led by biologist Dr Silvia von Karstedt has discovered two new ways to induce tumour cell death.

Chemistry - Pharmacology - 25.03.2021
Chemists achieve breakthrough in the production of three-dimensional molecular structures
Chemists achieve breakthrough in the production of three-dimensional molecular structures
A major goal of organic and medicinal chemistry in recent decades has been the rapid synthesis of three-dimensional molecules for the development of new drugs. These drug candidates exhibit a variety of improved properties compared to predominantly flat molecular structures, which are reflected in clinical trials by higher efficacy and success rates.

Pharmacology - Health - 24.03.2021
Hypnosis is beneficial for surgical patients
Hypnosis is beneficial for surgical patients
Meta-analysis reveals: Hypnosis relieves pain, reduces mental distress and promotes recovery after surgery Hypnosis relieves pain, reduces mental distress and promotes recovery after surgical interventions - this has been shown in a meta-analysis recently published in Clinical Psychology Review. By evaluating 50 individual studies with over 4000 patients, scientists from Jena and Leipzig examined the efficacy of hypnosis in the context of surgical interventions.

Pharmacology - Life Sciences - 05.03.2021
A new model can predict the evolution of antibiotic resistance in bacteria
An international research team has developed a model that predicts growth rates and resistance mechanisms of common bacterial mutants at different drug doses / Publication in 'Nature Ecology & Evolution' A team of scientists from the University of Cologne (Germany) and the University of Uppsala (Sweden) has created a model that can describe and predict the evolution of antibiotic resistance in bacteria.

Health - Pharmacology - 12.02.2021
Medication-based starvation of cancer cells
Medication-based starvation of cancer cells
Findings on cancer medication reveal protein regulation mechanism Immunomodulatory drugs, including the Contergan derivatives lenalidomide and pomalidomide have significantly improved the therapy of hematologic malignancies such as multiple myeloma. Researchers at the Technical University of Munich (TUM) have now further decoded the mode of action in this class of medications.

Health - Pharmacology - 12.02.2021
Synthetic -mini- receptors block atherosclerosis
New synthetic peptides could attenuate atherosclerosis Atherosclerosis, a lipid-triggered chronic inflammatory disease of our arteries, is the main cause of strokes and heart attacks. An international team of researchers led by the Technical University of Munich (TUM) and the LMU University Hospital has developed novel synthetic peptides that can help to prevent atherosclerosis in vitro, that is in the test tube, as well as in animal models.

Health - Pharmacology - 27.01.2021
New promising target for diabetes treatment
Blocking the receptor "inceptor" could protect insulin-producing beta cells One hundred years after the discovery of insulin and fifty years after that of the insulin receptor, researchers have now discovered a novel - and druggable - insulin inhibitory receptor, named inceptor. This could open up new possibilities for the treatment of diabetes: The blocking of inceptor function leads to an increased sensitisation of the insulin signaling pathway in pancreatic beta cells.

Health - Pharmacology - 11.01.2021
Polycystic kidney disease: Study explores diet as a key factor in kidney disease
Polycystic kidney disease: Study explores diet as a key factor in kidney disease
A new clinical study at the University of Cologne and Cologne University Hospital is investigating whether a ketogenic diet has a positive effect on patients with polycystic kidney disease / The trial is funded by the American PKD Foundation (polycystic kidney disease) A team of researchers at the University of Cologne is launching a study on the effects of ketogenic dietary regimens in patients affected by hereditary polycystic kidney disease (ADPKD).

Health - Pharmacology - 17.12.2020
Breathing rate predicts therapeutic benefits for heart patients
Discovering a forgotten biosignal Conditions causing arrhythmia are among the most common cardiac conditions. A study headed by Prof. Georg Schmidt of the Technical University of Munich (TUM) has demonstrated for the first time that the nocturnal respiratory rate can help with an important prediction: It is an indicator of whether a defibrillator will help to extend the life of patients with arrhythmia.

Health - Pharmacology - 05.12.2020
How Covid-19 Testing Can Become More Efficient
How Covid-19 Testing Can Become More Efficient
With the help of so-called pooling procedures, samples from different people can be combined into a pool and tested for Covid-19 collectively in a single test kit. An interdisciplinary team of mathematicians, computer scientists and medical doctors from the Junge Akademie, the Technische Universität Braunschweig, the Universität Stuttgart and the company Arctoris has developed a decision support tool that calculates which method is most effective in identifying all Covid-19 patients in a positive sample pool.

Health - Pharmacology - 02.11.2020
How the immune system remembers viruses
How the immune system remembers viruses
Immune response: memory T cells are formed earlier than previously thought For a person to acquire immunity to a disease, T cells must develop into memory cells after contact with the pathogen. Until now, the number of cells that do this was believed to depend above all on the magnitude of the initial immune response.

Pharmacology - Health - 23.10.2020
Is Antimicrobial Resistance Evolution Accelerating?
A team of researchers from Freie Universität Berlin and ETH Zurich studied if antifungal and antibiotic resistance emerge faster than in the past No 199/2020 from Oct 23, 2020 Scientists from Freie Universität Berlin and Eidgenössische Technische Hochschule Zürich (ETH Zurich) investigated how long it takes for resistance to emerge after the introduction of a new antifungal or antibiotic.

Health - Pharmacology - 13.10.2020
Safely on the way to effective tumour cell killing
Safely on the way to effective tumour cell killing
Scientists at the University of Göttingen develop drug for antibody tumour therapy Chemists at the University of Göttingen have developed new cytotoxic drugs which could revolutionise antibody-based tumour therapy approaches. The research team succeeded in modifying the natural product Duocarmycin into -prodrug- formats - which means that it only develops its effect once inside the tumour cell, thus reducing the likelihood of potential side effects on passage through the body.

Pharmacology - Health - 25.09.2020
Secure nano-carrier delivers medications directly to cells
Secure nano-carrier delivers medications directly to cells
Nanoparticles with synthetic DNA can control release of drugs Medications often have unwanted side-effects. One reason is that they reach not only the unhealthy cells for which they are intended, but also reach and have an impact on healthy cells. Researchers at the Technical University of Munich (TUM), working together with the KTH Royal Institute of Technology in Stockholm, have developed a stable nano-carrier for medications.

Pharmacology - Life Sciences - 02.09.2020
Finding cortisone alternatives with fewer side effects
Finding cortisone alternatives with fewer side effects
DNA binding is essential for effectiveness of steroids Many people use cortisone of a regular basis. It is used for treating rheumatism, asthma, multiple sclerosis, or even COVID-19. Steroidal medication such as cortisone is highly effective but also possesses severe side effects. Henriette Uhlenhaut, professor at Technical University of Munich (TUM), and her team are examining the beneficial effects of cortisone in order to lay the groundwork for the development of similar drugs with fewer side effects.

Pharmacology - Health - 07.08.2020
Intermittent Claudication: EffPac trial confirms benefit and safety of paclitaxel-coated balloon catheter
Intermittent Claudication: EffPac trial confirms benefit and safety of paclitaxel-coated balloon catheter
A study to balloon angioplasty with drug-coated and uncoated balloons in vascular occlusion in the femoropopliteal region proves the drug-coated devices to be superior Balloon angioplasty is the treatment option for the advanced stage of intermittent claudication - if medication and targeted training can no longer alleviate the pain and impairments caused by constricted leg arteries.

Chemistry - Pharmacology - 16.07.2020
Researchers solve a long-standing problem in organic chemistry
Researchers solve a long-standing problem in organic chemistry
Chemists at the University of Münster develop a bioinspired strategy for the controlled synthesis of polyenes / Study published in "Science" They occur in nature, are reactive and play a role in many biological processes: polyenes. It is no wonder that chemists have for a long time been interested in efficiently constructing these compounds - not least in order to be able to use them for future biomedical applications.

Health - Pharmacology - 23.06.2020
The tricks of the immune system
The tricks of the immune system
How the T-cell response changes in chronic virus infections "The Covid-19 pandemic clearly demonstrates the importance of understanding how the immune system reacts to virus infections," says Dr. Kilian Schober. Together with an interdisciplinary team of researchers from Medicine, Biology and Bioinformatics, he is investigating how important agents in the body's immune system known as T lymphocytes or T cells react when a virus invades the organism and how the immune response changes when the infection becomes chronic.

Pharmacology - Health - 05.06.2020
A newly discovered disease may lead to better treatment of cystic fibrosis
A newly discovered disease may lead to better treatment of cystic fibrosis
Cystic fibrosis is the most frequent severe inherited disorder worldwide. Every year, hundreds of families are confronted with this diagnosis - and to date, there is no cure for this disease that mainly affects the respiratory system. Besides supportive treatments, a lung transplant is often the only option to save a patient's live.

Health - Pharmacology - 03.06.2020
Remdesivir effective against Covid-19 even after short treatment periods
Remdesivir effective against Covid-19 even after short treatment periods
Comparable clinical results after five and ten days of treatment In an international study, scientists from eight countries have investigated the use of the medication Remdesivir in the treatment of Covid-19. One result of the study, which included the participation of the Technical University of Munich's university hospital TUM Klinikum rechts der Isar: The changes in the clinical condition of patients treated for five days were comparable to the changes in patients treated for a period of ten days.
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