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Pharmacology - Health - 30.03.2023
Health - Life Sciences - 27.03.2023 
Intestinal bacteria trigger postoperative complications
Previously, it was believed that a germ-free environment was the most critical factor in preventing postoperative infections. However, a recent study by Mercedes Gomez de Agüero's team from the Max Planck Research Group for Systems Immunology in Würzburg, Germany, in collaboration with the University Hospital of Bern, Switzerland, has revealed that the source of the danger is apparently entirely different: the patients' intestines.
Health - Pharmacology - 27.03.2023 
Components of Cytoskeleton Strengthen Effect of Sex Hormones
Researchers from Freiburg and Kiel discover that actin acts in the cell nucleus and is partly responsible for the expression of male sexual characteristics Steroid hormones, to which belong sex hormones like estrogen or testosterone, are important signaling molecules and are responsible among other things for controlling female and male phenotypic sex differentiation.
Health - Pharmacology - 24.03.2023
Health - Life Sciences - 23.03.2023 
Attack from the gut
Intestinal bacteria are often the trigger of complications after surgery. This is shown in a new study by research teams from Würzburg and Bern. A solution to this problem could come from the liver. Nearly 16 million operations were performed on inpatients in German hospitals in 2021. In Switzerland, the figure is around 1.1 million.
Materials Science - Health - 23.03.2023
Life Sciences - Health - 22.03.2023 
Beethoven’s genome
Scientists have sequenced the composer's genome using five genetically matching hair locks The study shows Beethoven was predisposed to liver disease, and infected with Hepatitis B, which - combined with his alcohol consumption - may have contributed to his death. Furthermore, DNA from modern relatives points to an extramarital 'event' in Beethoven's paternal line.
Life Sciences - Health - 22.03.2023 
Beethoven’s genome offers clues to composer’s health and family history
International team of scientists deciphers renowned composer's genome from locks of hair Ludwig van Beethoven's genome has been sequenced for the first time by an international team of scientists with the participation of the University of Bonn using five genetically matching locks of the well-known composer's hair.
Health - 21.03.2023 
New intracellular ’smoke detector’ discovered
Study by the University of Bonn could lead to therapies against skin and intestinal diseases in the medium term Researchers at the Universities of Bonn and Singapore have discovered a new intracellular "smoke detector." The sensor warns of damage to the mitochondria - the microscopic power plants that supply the cell with energy.
Health - Pharmacology - 21.03.2023 
Targeted computer modelling to accelerate antiviral drug development
Effective drugs against viral diseases like COVID-19 are urgently needed now and in the future. The emergence of viral mutants and yet unknown viruses could push vaccines to their limits. The DZIF scientist and bioinformatician Andreas Dräger from the University of Tübingen is working on a computer-based method that can help to accelerate the time-consuming identification and development of antiviral agents.
Health - Pharmacology - 20.03.2023 
Milestone in pulmonary hypertension therapy
In pulmonary arterial hypertension (PAH), the small vessels in the lungs become increasingly narrow and obstruct the transport of blood to the lungs. A new drug can stop this change and possibly even reverse it. Pulmonary arterial hypertension (PAH) is a special form of pulmonary hypertension. It occurs because the small arteries in the lungs narrow as a result of progressive changes in the blood vessels.
Life Sciences - Health - 16.03.2023 
Cellular waste removal differs according to cell type
Study by the University of Bonn identifies different types of so-called lysosomes "Miniature shredders" are at work in each cell, disassembling and recycling cell components that are defective or no longer required. The exact structure of these shredders differs from cell type to cell type, a study by the University of Bonn now shows.
Health - Life Sciences - 16.03.2023 
Neurology team researches mechanisms of repeated strokes
How can people be prevented from being affected again after a stroke? In order to find new therapeutic approaches for prevention, the international CRESCENDO consortium led by the MHH is conducting research at the molecular level. In Germany, 270,000 people suffer a stroke every year. This can result in severe disabilities: Paralysis, speech disorders and problems walking.
Health - 16.03.2023
Health - 15.03.2023 
Better care for pregnant women with precancerous cervical cancer
New test provides information on the progression of precancerous lesions Preliminary stages of cervical cancer occur mainly in women between 25 and 35 years of age. The main risk factor for developing cervical cancer is the human papillomavirus (HPV). Surgery is the treatment of choice. However, such an operation is problematic for pregnant women: since a piece of the uterus is removed, the risk of bleeding and premature birth increases because the cervix shortens and is no longer stable enough.
Pharmacology - Health - 14.03.2023 
Receptor ’blasting’ visualised
Adhesion GPCRs are a group of G protein-coupled receptors associated with many body functions and diseases. However, they have not yet been sufficiently studied to be used for therapies. Two research groups at the Rudolf Schönheimer Institute at the Faculty of Medicine at Leipzig University have now jointly developed a technology to change this.
Health - Life Sciences - 10.03.2023 
Immune cells have a backup mechanism
If the TBK1 enzyme is mutated, susceptibility to viral infections increases - unless it is missing The enzyme TBK1 is an important component of the innate immune system that plays a critical role in the defense against viruses. Upon mutation-induced loss of TBK1 function, patients show an increased susceptibility to viral infections.
Health - Life Sciences - 09.03.2023
Health - Life Sciences - 09.03.2023
Life Sciences - Health - 09.03.2023 
Major advance in super-resolution fluorescence microscopy
Pushing the MINFLUX technique to higher spatial and temporal precision allows protein dynamics to be observed under physiological conditions Scientists led by Nobel Laureate Stefan Hell at the Max Planck Institute for Medical Research in Heidelberg have developed a super-resolution microscope with a spatio-temporal precision of one nanometer per millisecond.
Health
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How to achieve a functional cure for chronic hepatitis B
More than half of people with chronic hepatitis B have a form of the disease in which the immune system almost never achieves sustained control, despite many years of treatment. According to current knowledge, those affected therefore require lifelong drug therapy. In the world's first study on the discontinuation of treatment with the common antiviral drug for the severe form called HBeAg-negative hepatitis B, scientists have shown that some patients can achieve sustained immune control if they discontinue the antiviral therapy after a certain period of time.
More than half of people with chronic hepatitis B have a form of the disease in which the immune system almost never achieves sustained control, despite many years of treatment. According to current knowledge, those affected therefore require lifelong drug therapy. In the world's first study on the discontinuation of treatment with the common antiviral drug for the severe form called HBeAg-negative hepatitis B, scientists have shown that some patients can achieve sustained immune control if they discontinue the antiviral therapy after a certain period of time.
Previously, it was believed that a germ-free environment was the most critical factor in preventing postoperative infections. However, a recent study by Mercedes Gomez de Agüero's team from the Max Planck Research Group for Systems Immunology in Würzburg, Germany, in collaboration with the University Hospital of Bern, Switzerland, has revealed that the source of the danger is apparently entirely different: the patients' intestines.
Researchers from Freiburg and Kiel discover that actin acts in the cell nucleus and is partly responsible for the expression of male sexual characteristics Steroid hormones, to which belong sex hormones like estrogen or testosterone, are important signaling molecules and are responsible among other things for controlling female and male phenotypic sex differentiation.
Novel Regulatory Mechanism of Blood Clotting Discovered
The glycoprotein V of the blood platelets is an important switch point for haemostasis and thrombus formation. This new finding could have great clinical potential. When our blood vessels are injured by cuts, abrasions, or bruises, it is vital that the bleeding is stopped, and the wound is sealed. This process is called hemostasis and involves two main components: First, blood platelets attach to the wound edges, form a plug and provisionally seal the injury.
The glycoprotein V of the blood platelets is an important switch point for haemostasis and thrombus formation. This new finding could have great clinical potential. When our blood vessels are injured by cuts, abrasions, or bruises, it is vital that the bleeding is stopped, and the wound is sealed. This process is called hemostasis and involves two main components: First, blood platelets attach to the wound edges, form a plug and provisionally seal the injury.
Intestinal bacteria are often the trigger of complications after surgery. This is shown in a new study by research teams from Würzburg and Bern. A solution to this problem could come from the liver. Nearly 16 million operations were performed on inpatients in German hospitals in 2021. In Switzerland, the figure is around 1.1 million.
RWTH research team creates the world’s first non-spherical microbubbles
Anisotropic microbubbles open up forward-looking possibilities for ultrasound imaging and drug delivery . An international research team led by Anshuman Dasgupta and Twan Lammers from the Institute for Experimental Molecular Imaging at RWTH Aachen University has succeeded for the first time in generating stable non-spherical microbubbles.
Anisotropic microbubbles open up forward-looking possibilities for ultrasound imaging and drug delivery . An international research team led by Anshuman Dasgupta and Twan Lammers from the Institute for Experimental Molecular Imaging at RWTH Aachen University has succeeded for the first time in generating stable non-spherical microbubbles.
Scientists have sequenced the composer's genome using five genetically matching hair locks The study shows Beethoven was predisposed to liver disease, and infected with Hepatitis B, which - combined with his alcohol consumption - may have contributed to his death. Furthermore, DNA from modern relatives points to an extramarital 'event' in Beethoven's paternal line.
International team of scientists deciphers renowned composer's genome from locks of hair Ludwig van Beethoven's genome has been sequenced for the first time by an international team of scientists with the participation of the University of Bonn using five genetically matching locks of the well-known composer's hair.
Study by the University of Bonn could lead to therapies against skin and intestinal diseases in the medium term Researchers at the Universities of Bonn and Singapore have discovered a new intracellular "smoke detector." The sensor warns of damage to the mitochondria - the microscopic power plants that supply the cell with energy.
Effective drugs against viral diseases like COVID-19 are urgently needed now and in the future. The emergence of viral mutants and yet unknown viruses could push vaccines to their limits. The DZIF scientist and bioinformatician Andreas Dräger from the University of Tübingen is working on a computer-based method that can help to accelerate the time-consuming identification and development of antiviral agents.
In pulmonary arterial hypertension (PAH), the small vessels in the lungs become increasingly narrow and obstruct the transport of blood to the lungs. A new drug can stop this change and possibly even reverse it. Pulmonary arterial hypertension (PAH) is a special form of pulmonary hypertension. It occurs because the small arteries in the lungs narrow as a result of progressive changes in the blood vessels.
Study by the University of Bonn identifies different types of so-called lysosomes "Miniature shredders" are at work in each cell, disassembling and recycling cell components that are defective or no longer required. The exact structure of these shredders differs from cell type to cell type, a study by the University of Bonn now shows.
How can people be prevented from being affected again after a stroke? In order to find new therapeutic approaches for prevention, the international CRESCENDO consortium led by the MHH is conducting research at the molecular level. In Germany, 270,000 people suffer a stroke every year. This can result in severe disabilities: Paralysis, speech disorders and problems walking.
Honeybees Navigate Using Mental Maps
Study with new findings on the waggle dance of honeybees published under the leadership of zoologist and neurobiologist Professor Randolf Menzel of Freie Universität Berlin According to a recent study, honeybees have a map-like spatial memory of their territory and are able to fly from their starting location to any destination encoded in a waggle dance.
Study with new findings on the waggle dance of honeybees published under the leadership of zoologist and neurobiologist Professor Randolf Menzel of Freie Universität Berlin According to a recent study, honeybees have a map-like spatial memory of their territory and are able to fly from their starting location to any destination encoded in a waggle dance.
New test provides information on the progression of precancerous lesions Preliminary stages of cervical cancer occur mainly in women between 25 and 35 years of age. The main risk factor for developing cervical cancer is the human papillomavirus (HPV). Surgery is the treatment of choice. However, such an operation is problematic for pregnant women: since a piece of the uterus is removed, the risk of bleeding and premature birth increases because the cervix shortens and is no longer stable enough.
Adhesion GPCRs are a group of G protein-coupled receptors associated with many body functions and diseases. However, they have not yet been sufficiently studied to be used for therapies. Two research groups at the Rudolf Schönheimer Institute at the Faculty of Medicine at Leipzig University have now jointly developed a technology to change this.
If the TBK1 enzyme is mutated, susceptibility to viral infections increases - unless it is missing The enzyme TBK1 is an important component of the innate immune system that plays a critical role in the defense against viruses. Upon mutation-induced loss of TBK1 function, patients show an increased susceptibility to viral infections.
French-German Team Refutes Standard Model of Electroporation
Technology developed at University of Freiburg enables experimental test Strong electric fields can be used to create pores in biomembranes. The method is known as electroporation. Inducing such defects in membranes in a targeted manner is an important technique in medicine and biotechnology, but also in the treatment of foodstuffs.
Technology developed at University of Freiburg enables experimental test Strong electric fields can be used to create pores in biomembranes. The method is known as electroporation. Inducing such defects in membranes in a targeted manner is an important technique in medicine and biotechnology, but also in the treatment of foodstuffs.
New stem cell model developed for research into a life-threatening malformation of the newborn lung
Study investigates cause and new therapeutic approach for congenital diaphragmatic hernia Congenital diaphragmatic hernia is one of the deadliest birth defects. To better understand and treat this condition in the future, an international team of researchers involving Leipzig University Hospital designed a new cell model in the laboratory and tested a drug therapy on it.
Study investigates cause and new therapeutic approach for congenital diaphragmatic hernia Congenital diaphragmatic hernia is one of the deadliest birth defects. To better understand and treat this condition in the future, an international team of researchers involving Leipzig University Hospital designed a new cell model in the laboratory and tested a drug therapy on it.
Pushing the MINFLUX technique to higher spatial and temporal precision allows protein dynamics to be observed under physiological conditions Scientists led by Nobel Laureate Stefan Hell at the Max Planck Institute for Medical Research in Heidelberg have developed a super-resolution microscope with a spatio-temporal precision of one nanometer per millisecond.
