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Bonn researchers link immune cells to higher risk of duodenal carcinoma in hereditary FAP People with the hereditary disease familial adenomatous polyposis (FAP) have a greatly increased risk of developing a malignant tumor of the duodenum. Researchers at the University Hospital Bonn (UKB) and the Cluster of Excellence ImmunoSensation2 at the University of Bonn have now discovered a mechanism in the local immune system that can drive the development of cancer.

University of Bonn-guided study leads to the discovery of a promising receptor blocker Irritable bowel syndrome, chronic itching, asthma and migraine are in many cases hard-to-treat conditions. They have in common that they are triggered by an excessive immune response-which in severe cases can be life-threatening.

Researchers at the MPI of Biochemistry have used spatial Deep Visual Proteomics workflow to reveal why some patients with the hereditary disease alpha-1 antitrypsin deficiency remain healthy despite the genetic defect.

New insights into dopamine in focal cortical dysplasia: For the first time, a research team in Bonn is systematically investigating the role of the dopamine system in a common form of therapy-resistant epilepsy. Focal cortical dysplasia (FCD) type 2 is a congenital malformation of the cerebral cortex that is often associated with difficult-to-treat epilepsy.

Pathogenic salmonella inject effector proteins into the cells of the stomach and intestinal tissue in order to penetrate and multiply there. The bacteria, which are usually ingested with food, cause dangerous gastrointestinal inflammation and even systemic infections, especially in children and the elderly.

Researchers at the university hospitals in Jena, Aachen, Essen, Halle and Leipzig have developed an app that supports doctors in the treatment of bloodstream infections with staphylococci. The app was evaluated in a large prospective multicentre study at five university hospitals with more than 5,000 patients.

A team from the Max Planck Research Group for Systems Immunology at the University of Würzburg has identified a previously unknown phase of the immune response. These new insights have significant implications for the development of vaccines and cellular immunotherapies. The research groups led by Wolfgang Kastenmüller and Georg Gasteiger employed innovative microscopy techniques to observe how specific immune cells, known as T'cells, are activated and proliferate during a viral infection.

The detection of peripheral neural stem cells could transform the treatment of Parkinson's disease and spinal cord injuries To the point Peripheral neural stem cells: Researchers have discovered a new type of neural stem cell in the lungs of mice. These cells have similar properties to the known neural stem cells in the brain, including self-rejuvenation and differentiation ability.

To the point Induction of Multicellularity : When mechanically compressed, the salt-loving archaeon Haloferax volcanii can shift from being single-celled to forming tissue-like clusters, displaying new mechanical and biological properties. Insights into Evolution : This study challenges current thinking about evolution by showing that physical forces and genetic changes can work together to promote the development of complex life forms, suggesting that multicellularity might arise more easily than we previously imagined.

Research team led by Göttingen University challenges conventional poverty metrics   Two billion people globally suffer from moderate to severe food insecurity and widespread micronutrient deficiencies. This contrasts with 654 million people who are classified as extremely poor according to the World Bank's US$2.15 per day International Poverty Line (IPL).

To the point A neuroimaging study examined the processing of pain signals in the brain as participantswatched virtual nature videos. Participants reported less pain and showed lower activity in brain regions associated with specific pain processing. The findings underscore the importance of nature-based therapeutic approaches in pain management.

Würzburg researchers present a new strategy against the life-threatening fungus Aspergillus fumigatus. They combine RNA molecules and an antifungal agent in nanoparticles. Fungal infections are on the rise globally. According to a study by the Manchester Fungal Infection Group , in 2022, approximately 6.5 million people were infected by a pathogenic fungus, and about 3.8 million died as a result - nearly twice as many as in 2012.

Researchers from Bonn and Tübingen revise an established theory of stimulus processing in nerve cells during memory processing How does the brain retain a sequence of events in memory? Researchers from the University Hospital Bonn (UKB), the University of Bonn, the University Hospital Tübingen and the University of Tübingen investigated this question.

When plants are attacked by pathogenic bacteria, they use chemical and electrical signals to transmit the information from the point of origin on the leaf surface to the inside and go into defence mode. In order to find out how and where the perception of bacterial contact is converted into electrical signals, a research team led by PD Dr Alexandra Furch from the University of Jena investigated how the external stimulus is transmitted.

A newly developed laboratory tool can, within hours, help to identify specific viruses which can be used to destroy variants of the dangerous pathogenic bacteria Staphylococcus aureus. Viruses of bacteria, known as bacteriophages, offer an alternative approach to antibiotics in treating multiresistant pathogens.

A research team at Leipzig University Medicine has found a possible cause for the development of Long Covid. The disruption of certain signaling pathways in the nervous system plays an important role in this. In addition, the positive effect of nicotine patches on Long Covid symptoms was demonstrated for the first time using imaging as part of these therapeutic trials.

In an international study, researchers have examined different fat cells in adipose tissues of the human body. Using innovative technology, they were able to identify unique subpopulations of fat cells for the first time and determine differences between human fat tissues in intercellular communication.

Half a million people worldwide are diagnosed with esophageal cancer every year. It is one of the deadliest forms of cancer. A study with significant involvement from Leipzig University Medicine shows how the chances of recovery for patients can be improved. The results were published in the renowned New England Journal of Medicine.

Did you know that a woman's heartbeat changes in subtle ways during her menstrual cycle? These rhythmic changes, triggered by hormonal fluctuations, offer a unique insight into the complex interactions between the female brain and heart. In a new paper published in Science Advances, Max Planck researchers Jellina Prinsen, Julia Sacher and Arno Villringer explain how these naturally occurring fluctuations could affect stress, mood and long-term cardiovascular and neurological health.

Researchers reveal new insights into the how the matrix layer of HIV-1 becomes mature Researchers from the Max Planck Institute of Biochemistry have discovered the mechanism behind an important step in the life cycle of HIV. Working together with teams at Heidelberg and Yale Universities, they found that the enigmatic -spacer peptide 2-, one of the virus components, plays a key role in converting immature HIV-1 particles into infectious particles.