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News from the Lab (news.myScience.ch)

  • News from the Lab’ is a selection of scientific works that are significant or interesting for a broad readership. 
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Pharmacology - Health - 26.03.2020
Medications against coronavirus in trial
Clinical trials on Covid-19 at university hospital TUM Klinikum rechts der Isar The university hospital is participating in studies on new medications for people suffering from Covid-19. As part of a clinical study, patients can be treated with medications that are still under development. 50 patients infected with the novel Coronavirus are currently being treated at the university hospital TUM Klinikum rechts der Isar.

Life Sciences - Health - 25.03.2020
A new mechanism triggering cell death and inflammation: a left turn that kills
Z-form nucleic acids are double-stranded DNA and RNA molecules with an unusual left-handed double helix structure, as opposed to the classical right-handed Watson-Crick double helix. Z-nucleic acids were discovered more than 40 years ago, but their biological function has remained poorly understood.

Health - 20.03.2020
Health forums: Style of language influences credibility and trust
Health forums: Style of language influences credibility and trust
More and more, people are using internet forums as first place to look for information on health issues. However, the scientific medical information being provided there is often so complex that laypeople are barely able to form considered judgements on the content of much of the advice. One criterion which users apply instead in evaluating the information is the style of the language used.

Health - Life Sciences - 17.03.2020
Blocking sugar structures on viruses and tumor cells
Blocking sugar structures on viruses and tumor cells
Coronavirus: University operations limited +++ make use of online services +++ many staff working from home +++ www.tum.de/corona Artificial sugar-binding protein may inhibit cell growth During a viral infection, viruses enter the body and multiply in its cells. Viruses often specifically attach themselves to the sugar structures of the host cells, or present characteristic sugar structures on their surface themselves.

Life Sciences - Health - 13.03.2020
Analysis of whole brain vasculature
Analysis of whole brain vasculature
Coronavirus: University operations limited +++ make use of online services +++ many staff working from home Biochemical methods and AI show even the finest capillaries Diseases of the brain are often associated with typical vascular changes. Now, scientists at LMU University Hospital Munich, Helmholtz Zentrum München and at the Technical University of Munich (TUM) have come up with a technique for visualising the structures of all the brain's blood vessels - right down to the finest capillaries - including any pathological changes.

Health - 10.03.2020
Fatal overproduction of antibodies
Fatal overproduction of antibodies
Mutations in plasma cells play a key role in light chain amyloidosis Bone marrow plasma cells produce antibodies. These comprise two long and two short protein chains. The pathological proliferation of plasma cells can lead to an overproduction of the short chains. These associate to fibrils and deposit in organs.

Health - 05.03.2020
Towards improved cochlear implants
Towards improved cochlear implants
Computer model shows neuronal activation patterns in the inner ear Research towards improved cochlear implants Cochlear implants restore hearing in deaf people to an amazingly high level. In order to optimize such implants, researchers at the Technical University of Munich (TUM) have developed a computer model which predicts the neuronal activation patterns that the implant creates in the auditory nerve fibers.

Life Sciences - Health - 05.02.2020
The invisibility cloak of a fungus
The invisibility cloak of a fungus
While viruses and bacteria regularly manage to infect the human organism, fungi only very rarely succeed. The reason for this is that the human immune system can recognize them very easily because their cells are surrounded by a solid cell wall of chitin and other complex sugars. Chitin is, so to speak, the alarm signal for our immune system, to which it reacts with a whole arsenal of defensive weapons.

Pharmacology - Health - 04.02.2020
Hepatitis B: New therapeutic approach
Hepatitis B: New therapeutic approach
Therapeutic vaccination may help to cure chronic hepatitis B infection Researchers at Technical University of Munich (TUM), Helmholtz Zentrum München and the German Center for Infection Research (DZIF) have developed a novel therapeutic approach to cure chronic hepatitis B. The scientists found that the large amount of hepatitis B virus proteins expressed in the liver prevents the body's immune system to defeat the virus.

Health - Pharmacology - 04.02.2020
What can be done to combat the third leading cause of death worldwide?
Freie Universität Berlin participates in international research project to develop new therapies against antibiotic-resistant pathogens of pneumonia / Funded with 10 million euros from the European Union No 025/2020 from Feb 04, 2020 Scientists from eleven European research institutions, including the Institute of Pharmacy at Freie Universität Berlin, are jointly looking for new ways to combat antibiotic-resistant pathogens.

Health - Life Sciences - 27.01.2020
Gene scissors against incurable muscular disease
Gene scissors against incurable muscular disease
New gene correction therapy for Duchenne muscular dystrophy Duchenne type muscular dystrophy (DMD) is the most common hereditary muscular disease among children, leaving them wheelchair-bound before the age of twelve and reducing life expectancy. Researchers at Technical University of Munich (TUM), Ludwig Maximilian University of Munich (LMU) and the German Research Center for Environmental Health (Helmholtz Zentrum München) have developed a gene therapy that may provide permanent relief for those suffering from DMD.

Life Sciences - Health - 23.01.2020
Researchers reconstruct 500 million years of insect evolution
Researchers reconstruct 500 million years of insect evolution
Arthropods, a group of animals including next to insects also spiders or crustaceans, make up the most species-rich and diverse group of animals on Earth, with numerous adaptations that have allowed them to exploit all major ecosystems. However, what genetic mechanisms are responsible for their great evolutionary success' A team of international researchers studied now these species and tracked the evolutionary origin of key adaptations.

Health - Pharmacology - 18.12.2019
Using AI to understand the spread of cancer
Using AI to understand the spread of cancer
New deep learning algorithm DeepMACT detects the smallest metastases Researchers at the Technical University of Munich (TUM), the Helmholtz Zentrum München and the LMU Munich have developed a new algorithm that automatically detects metastases. The new technology uses artificial intelligence (AI) and even finds single disseminated cancer cells in the body of mice.

Pharmacology - Health - 16.12.2019
From cancer medication to antibiotic
From cancer medication to antibiotic
Modified cancer drug effective against multi-resistant bacteria Antibiotic-resistant bacteria are increasingly the source of deadly infections. A team of scientists from the Technical University of Munich (TUM) and the Helmholtz Center for Infection Research (HZI) in Braunschweig have now modified an approved cancer drug to develop an active agent against multidrug-resistant pathogens.

Health - 25.11.2019
Regeneration of nerve cells, 3D printing in construction
Regeneration of nerve cells, 3D printing in construction
DFG funds two new TUM transregional Collaborative Research Centers Regeneration of nerve cells, 3D printing in construction The German Research Foundation (Deutsche Forschungsgemeinschaft or DFG) is funding two new transregional Collaborative Research Centers (SFB/Transregional research alliance) involving the Technical University of Munich (TUM).

Pharmacology - Health - 14.10.2019
Inactive receptor renders immunotherapies ineffective
Inactive receptor renders immunotherapies ineffective
The aim of immunotherapies is to enable the immune system once again to fight cancer on its own. Drugs known as checkpoint inhibitors are already in clinical use for this purpose. However, they are only effective in about one third of patients. Based on analysis of human tissue samples, a team from the Technical University of Munich (TUM) has now discovered one reason why this is so: an inactive receptor in cancer cells prevents the drugs from reactivating the immune system.

Health - Life Sciences - 09.10.2019
Tuberculosis: New insights into the pathogen
Researchers at the University of Würzburg and the Spanish Cancer Research Centre have gained new insights into the pathogen that causes tuberculosis. Tuberculosis is a highly contagious infectious disease that is typically spread through aerosols and mainly affects the lungs. According to the World Health Organization (WHO), an estimated 1.7 million people die from such an infection worldwide every year.

Health - Life Sciences - 02.10.2019
Weak spot in pathogenic bacteria
Weak spot in pathogenic bacteria
Antibiotics are still the most important weapon for combatting bacterial infections. But medical science is running out of "ammunition" because of more and more frequently occurring resistances. A research team has now elucidated the structure of the proteolytic complex ClpX-ClpP. This is a key to development of innovative antibiotics which target the degradation process of defective proteins in bacteria.

Pharmacology - Health - 02.10.2019
New approach to pain treatment in diseases of the pancreas
New approach to pain treatment in diseases of the pancreas
One of the worst symptoms associated with inflammation or cancer of the pancreas is severe chronic pain. Pancreatic pain is difficult to treat, because many painkillers prove ineffective in pancreatic patients. In a recent study, a team at the Technical University of Munich (TUM) discovered the cause of this phenomenon for the first time: a particular neuroenzyme in the body is present in the nerves of the organ in high concentrations.

Life Sciences - Health - 01.10.2019
A timekeeper for siesta
External stimuli can rearrange the hierarchy of neuronal networks and influence behaviour. This was demonstrated by scientists from the universities of Würzburg and Brandeis using the circadian clock of the fruit fly as an example. Circadian clocks must be flexible and they must be able to adapt to varying environmental conditions.
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