Unlocking the World of Bacteria

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Employing IMPRINT, the researchers could significantly boost DNA transformation
Employing IMPRINT, the researchers could significantly boost DNA transformation in Salmonella. (Image: HZI / Manfred Rohde)
Researchers at the Würzburg Helmholtz Institute for Infection Research led by RNA expert Chase Beisel have developed a new approach to DNA transformation and gene mutation in bacteria.

Bacteria possess unique traits with great potential for benefiting society. However, current genetic engineering methods to harness these advantages are limited to a small fraction of bacterial species. A team led by the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg has now introduced a novel approach that can make many more bacteria amenable to genetic engineering. Their method, called IMPRINT, uses cell-free systems to enhance DNA transformation across various bacterial strains. The findings were published today in the journal Molecular Cell. ...
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