Turning One into Eight

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University of Bonn chemists invent technique for producing variants of natural substances

The team of the Kekulé Institute for Organic Chemistry and Biochemistry: - (from
The team of the Kekulé Institute for Organic Chemistry and Biochemistry: - (from left) Katharina Pieper, Andreas Gansäuer, Christian Köhler and Regine Mika from the Kekulé Institute for Organic Chemistry and Biochemistry at the University of Bonn. © Photo: Volker Lannert / University of Bonn all’images in original size .
To synthesize potential drugs or natural products, you need natural substances in specific mirror-image variants and with a high degree of purity. For the first time, chemists at the University of Bonn have succeeded in producing all’eight possible variants of polypropionate building blocks from a single starting material in a relatively straightforward process. Their work has now been published in the prestigious journal "Angewandte Chemie."

Polypropionates are natural products that can help save lives. They are needed to make reserve antibiotics, compounds that are only ever used to treat infections caused by drug-resistant bacteria. ...
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