Tumor cells evade the immune system early on

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Many tumors secrete prostaglandin E2. This prevents stem cell-like T cells from
Many tumors secrete prostaglandin E2. This prevents stem cell-like T cells from differentiating into cells that attack the cancer. Jan Böttcher (left) and first author Sebastian Lacher have deciphered the mechanism behind this.


Newly discovered mechanism could significantly improve cancer immunotherapies

Tumors actively prevent the formation of immune responses by so-called cytotoxic T cells, which are essential in combating cancer. Researchers at the Technical University of Munich (TUM) and the Ludwig-Maximilians-Universität München (LMU) Hospital have now uncovered for the first time how this exactly happens. The study in the journal "Nature" provides rationales for new cancer immunotherapies and could make existing treatments more effective. A second paper in "Nature" confirms the findings.

In cancer, tumors often impair the body’s immune response. ...
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