The Route Into the Cell Influences the Outcome of Sars-Cov-2 Infection

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Electron microscopy reveals the initial stages of the Sars-Cov-2 infection proce
Electron microscopy reveals the initial stages of the Sars-Cov-2 infection process at 40,000-fold magnification. Four coronaviruses can be seen attached to pits in the cell membrane via their elongated spike proteins. These viruses are now primed for cell uptake into vesicles. A single internalized virion can also be seen, located in an intracellular vesicle with a characteristic protein coat. Sara Calvo Ibanez, Regina Eberle und Jacomina Krijnse Locker
A surface protein helps viruses to enter cells. This has far-reaching consequences for the infection.

How exactly do Sars-Cov-2 particles enter host cells? An international team led by Dr Richard Brown from Dr Daniel Todt’s Computational Virology group at the Department of Molecular and Medical Virology at Ruhr University Bochum, Germany, together with researchers from the Paul-Ehrlich-Institut, investigated this question. The researchers were able to show how the protein TMPRSS2 acts as a helper to bring the virus into the cell via the receptor ACE2. This TMPRSS2-mediated uptake significantly alters the immune response of the host cells and drives the evolution of the virus. ...
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