A team of chemists at the University of Münster has developed a synthesis method for the site-selective integration of the biologically relevant difluoromethyl group into pyridines
With their newly developed method, chemists can precisely incorporate a difluoromethyl group (highlighted in light blue) regioselectively, i.e. at certain positions, into pyridine rings - either in the para-position (yellow arrow) or the meta-position (blue arrow). The nitrogen atom within the pyridine ring is shown in dark blue. The difluoromethyl group often determines the properties of bioactive molecules and is therefore particularly interesting for drug research. This atomic group consists of carbon, two fluorine atoms and a hydrogen atom. Derivatives of the chemical compound pyridine are particularly suited for inclusion in difluoromethyl groups. If a hydrogen atom in pyridines is replaced by such a group, difluoromethylated ring structures can be obtained in an uncomplicated way, which are potential candidates for new drugs and agrochemicals.
... TO READ THIS ARTICLE, CREATE YOUR ACCOUNT And extend your reading, free of charge and with no commitment.
