New Mechanism of Action Kills Cancer Cells

A team headed by Johannes Karges has developed a novel metal complex that trigge
A team headed by Johannes Karges has developed a novel metal complex that triggers a form of cell death in cancer cells that has only recently been identified. © RUB, Marquard
In a first, a Bochum-based team has produced a substance capable of sending cancer cells into ferroptosis, that is a specific form of cell death. This could pave the way for the development of new drugs.

Conventional cancer drugs work by triggering apoptosis, that is programmed cell death, in tumor cells. However, tumor cells have the ability to develop strategies to escape apoptosis, rendering the drugs ineffective. In the journal "Angewandte Chemie", a research team from Ruhr University Bochum, Germany, describes a new mechanism of action that kills cancer cells through ferroptosis. Ferroptosis is another form of programmed cell death that wasn’t discovered until the 2010s. ...
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