More clarity on hereditary colorectal cancer
Bonn researchers reclassify leading gene variants, a large proportion of them as benign
Research work led by Bonn researchers reduces gene variants of uncertain significance (VUS) in hereditary colorectal cancer: (from left) Isabel Spier and Stefan Aretz © University Hospital Bonn (UKB) / Inka Väth all’images in original size . The genetic confirmation of a suspected diagnosis of "hereditary colorectal cancer" is of great importance for the medical care of affected families. However, many of the variants identified in the known genes cannot yet be reliably classified in terms of their causal role in tumor formation. Under the leadership of the University Hospital Bonn (UKB) and the University of Bonn, an international team of researchers has reassessed the medical relevance of a significant number of unclear variants and thus significantly reduced their number. ...TO READ THIS ARTICLE, CREATE YOUR ACCOUNT
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