Leipzig biophysicists decipher functionality of adrenaline-binding receptor

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Binding to the receptor (green) causes the G protein (yellow) to change its shap
Binding to the receptor (green) causes the G protein (yellow) to change its shape and release the regulatory molecule GDP. Photo: Peter W. Hildebrand

G protein-coupled receptors (GPCRs) are found throughout the human body and are involved in many complex signalling pathways. Despite their importance in many biological processes, the central mechanism of G protein-coupling and the associated signal transmission is not yet understood. A team of researchers from Leipzig University has succeeded in understanding the mechanism of signal transmission through an adrenaline-binding receptor at the atomic level. In the future, researchers may be able to use these results to better avoid side effects when developing drugs. The study has been published in the journal Nature Structural & Molecular Biology.

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