Key player in viral heart inflammation discovered

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Characteristic stripes (green) make the heart muscle cell (cardiomyocyte) easily
Characteristic stripes (green) make the heart muscle cell (cardiomyocyte) easily recognisable. The virus infection in this cell is shown by viral RNA which has been coloured red. Image: Freiburg University Medical Centre (Hanna Wolf, AG Lindner, Department of Cardiology and Angiology)

Inflammation of the heart muscle following a viral infection can impede cardiac function in the long term

Inflammation of the heart muscle, also known as myocarditis, is a serious consequence of a viral infection. This can impede the heart’s ability to pump blood in the long term. In a current study, researchers of the Faculty of Medicine of the University of Freiburg have discovered a new approach for treating myocarditis. The research team used an animal model to show that the immune cell receptor GPR15 plays a crucial role in combating viruses in cardiac tissue. If these receptors are not present, elimination of the virus is slower, which could consequentially weaken the heart. ...

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