Insight into the molecular mechanisms of ALS

There are hardly any drugs against ALS. A new study shows that a substance actin
There are hardly any drugs against ALS. A new study shows that a substance acting on the MAPK signaling pathway may help: After treatment with trametinib, mouse nerve cells (blue) survived better than without.


Newly discovered subtypes and sex differences create new approaches for drugs

Amyotrophic lateral sclerosis, ALS for short, is a mysterious neurodegenerative disease that is almost always fatal. A consortium of researchers led by the Technical University of Munich (TUM) has systematically investigated the underlying molecular mechanisms of ALS. Among other things, the team discovered that ALS can be divided into subtypes. Depending on the subtype, different drugs could be effective. There are also clear differences in the molecular processes when comparing men and women.

The molecular processes in the body that cause ALS patients to increasingly lose control of motor functions are still poorly understood. ...
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