Early life adversity leaves long-term signatures in baboon DNA

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Study shows multiple pathways connect early life adversity to later life health

Juvenile baboons in Amboseli National Park in Kenya. The researchers combined DN
Juvenile baboons in Amboseli National Park in Kenya. The researchers combined DNA methylation data with ecological, behavioral, and life history data collected at the Amboseli study site. © Susan Alberts

Early experiences in an animal’s life can have a significant impact on its capacity to thrive, even years or decades later, and DNA methylation may help record their effects. In a study of 256 wild baboons, researchers from the Max Planck Institute for Evolutionary Anthropology and Duke University found that resource limitation during early life was associated with many differences in DNA methylation, a small chemical mark on the DNA sequence that can affect gene activity. Resource limitation was more important than other types of early environmental stressors, suggesting the particular importance of resource deprivation in the first years of life. ...

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