The figure shows the experimental data derived from the cryo EM experiments as a 3D reconstruction. The XPD protein is depicted in green, the accessory factor p44 in cyan, and the damaged DNA is shown in orange. The data provides information up to 3.1 Å (one Å corresponds to one hundred-millionth of a centimeter) resolution, allowing to observe atomic details of XPDs interaction with the damaged DNA. (Image: Jochen Kuper/JMU)Researchers at the University of Würzburg, led by Caroline Kisker in cooperation with Claudia Höbartner, discovered how the protein XPD detects a severe DNA damage and controls its repair.
The XPD protein is a central component of our body’s own ’DNA repair team’, known as nucleotide excision repair (NER). Like a sniffer dog, NER detects marked areas of damage, tracks down the damaged DNA and recruits other repair proteins to cut out and replace the defective sections. In healthy people, for example, XPD prevents the development of skin cancer by detecting and repairing UV-damaged DNA. ...
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