An enzyme makes mushrooms ’magical’

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Dirk Hoffmeister at the Institute of Pharmacy at Friedrich Schiller University J
Dirk Hoffmeister at the Institute of Pharmacy at Friedrich Schiller University Jena. Image: Jens Meyer (University of Jena)

An international research team has investigated the biosynthesis of psilocybin, the main ingredient of hallucinogenic mushrooms. They gained new insights into the structure and reaction mechanism of the enzyme PsiM. It plays a key role in the production of psilocybin. The results of the study were published in the journal "Nature Communications". 

The psychoactive substance psilocybin is the most important natural product of so-called "magic mushrooms" of the genus Psilocybe, which makes these mushrooms a popular drug. However, psilocybin has also become increasingly interesting in medicine in recent years for a number of mental illnesses. It has shown promising results in the treatment of depression, addiction and anxiety. ...

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