Alzheimer’s disease: It’s not only neurons

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Not only neurons build the protein amyloid beta (blue), which clumps together an
Not only neurons build the protein amyloid beta (blue), which clumps together and forms harmful plaques in Alzheimer’s disease: Special glial cells of the brain - the oligodendrocytes (orange) - also produce such deposits. Myelin, which insulates neurons, is stained white. © MPI f. Multidisciplinary Sciences / Andrew Octavian Sasmita

Memory loss, confusion, speech problems - Alzheimer’s disease is the most common cause of dementia, affecting about 35 million people worldwide, and the number is growing. The protein amyloid beta, which occurs naturally in the brain, plays a central role in the disease: It accumulates in patients in insoluble clumps that form plaques between neurons in the brain, damaging them. Researchers at the Max Planck Institute (MPI) for Multidisciplinary Sciences have now shown that, in addition to neurons, special glial cells in the brain also produce amyloid beta. This finding could open up new avenues for future therapies.

There is no cure for Alzheimer’s disease. However, there are therapeutic approaches to reduce the amyloid plaques in the brain. ...

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