When the Cellular Waste Collector Doesn’t Show Up

- EN - DE
Verian Bader and Konstanze Winklhofer (right) are on the trail of the developmen
Verian Bader and Konstanze Winklhofer (right) are on the trail of the development of neurodegenerative diseases. RUB, Marquard
Researchers have identified a mechanism that promotes the breakdown of harmful protein deposits. If it malfunctions, it can lead to Parkinson’s disease.

NEMO, a protein that is primarily associated with signaling processes in the immune system, prevents the deposition of protein aggregates that occur in Parkinson’s disease. For this purpose, it binds to certain protein chains that serve as markers for cellular waste removal, thus promoting the degradation of the harmful aggregates. A research team headed by Professor Konstanze Winklhofer from Ruhr University Bochum, Germany, has shed light on how this mechanism works. The team published their findings in the journal Nature Communications from December 19, 2023. ...
account creation

TO READ THIS ARTICLE, CREATE YOUR ACCOUNT

And extend your reading, free of charge and with no commitment.