Viral Impostors: Breakthrough for Virus Research

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An innovative method makes it possible to precisely detect viruses and visualise
An innovative method makes it possible to precisely detect viruses and visualise them in three dimensions. This opens up new horizons for virus research. (Image: Gerti Beliu / RVZ, erstellt mit DALL·E 3)
The penetration of viruses into cells can now be tracked with unprecedented accuracy thanks to Würzburg researchers and their innovative design for pseudoviruses.

Pseudoviruses resemble impostors: although harmless, they are designed in such a way that they can hardly be distinguished from their dangerous relatives. This makes them an invaluable tool in virus research. They can be used to precisely analyze infection pathways of dangerous virus variants.

A major challenge in this research area so far has been to make the pseudoviruses reliably visible under the microscope. This is because conventional labelling methods impair the activity of the "impostors" and thus falsify the imaging. ...
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