Releasing Brakes on Biocatalysis

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Anja Hemschemeier, Jifu Duan and Eckhard Hofmann (from left) worked together on
Anja Hemschemeier, Jifu Duan and Eckhard Hofmann (from left) worked together on the study. © RUB, Marquard
Formaldehyde can inhibit enzymes that produce hydrogen particularly efficiently. Researchers from Bochum have discovered how this can be prevented.

Enzymes from microorganisms can produce hydrogen (H2) under certain conditions, which makes them potential biocatalysts for biobased H2 technologies. In order to make this hydrogen production efficient, researchers are trying to identify and eliminate possible limiting factors. These include formaldehyde, which occurs naturally as a metabolic product in cells and inhibits the particularly efficient [FeFe] hydrogenase. A team from the work group Photobiotechnology at Ruhr University Bochum, Germany, was able to elucidate and switch off the underlying mechanism. ...
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