PicoRuler: Molecular Rulers for High-Resolution Microscopy

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PicoRuler: Protein-based molecular rulers make it possible to test the optical r
PicoRuler: Protein-based molecular rulers make it possible to test the optical resolution of the latest super-resolution microscopy methods on biomolecules in the sub-10-nanometre range under realistic conditions. (Image: Gerti Beliu / Universität Würzburg, erstellt mit DALL·E 3)

Good news for researchers working with high-resolution fluorescence microscopy: Biocompatible molecular rulers are available for the first time to calibrate the latest super-resolution microscopy methods.

Latest super-resolution microscopy methods now achieve an optical resolution in the range of a few nanometres. This corresponds to a resolution in the range of the size of cellular molecules. ...

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