Improving the efficacy of cancer immunotherapy with modified CAR-T cells

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Watercolour illustrating the signalling chains of the natural T cell receptor. I
Watercolour illustrating the signalling chains of the natural T cell receptor. Image: Sara Wossning Minguet (detailed caption: see text)
Freiburg researchers achieved a significantly improved anti-tumour efficacy of CAR-T cells in a preclinical model

CAR-T cell therapy is a last hope for many patients with blood, bone marrow or lymph gland cancer when other treatments such as chemotherapy are unsuccessful. A limiting factor of this otherwise very effective and safe therapy is that the cells used in the process quickly reach a state of exhaustion. Researchers at the University of Freiburg have now been able to prevent this exhaustion and thus significantly improve the effect of the therapy in a preclinical animal model. The new results have been published in the journal Nature Immunology. ...
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