Illustration of the interacting thick and thin filaments in the cardiac sarcomere based on structural cryo electron-tomography data.
An international team, led by Stefan Raunser, Director at the Max Planck Institute of Molecular Physiology in Dortmund, in collaboration with Mathias Gautel at King’s College London, has successfully obtained the world’s first high-resolution 3D image of the thick filament in its natural cellular environment, utilizing a cutting-edge technique known as electron cryo-tomography. This offers a glimpse into the molecular organization and arrangement of the components within the thick filament. The newfound insight is nothing short of a crucial framework for comprehending how muscles operate in both health and disease. The human heart, often described as the body's engine, is a remarkable organ that tirelessly beats to keep us alive.
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