Around 2 billion people worldwide are overweight. Obesity increases the risk of developing high blood pressure, heart attack or type 2 diabetes mellitus and can cause inflammation in the body that weakens the immune system through an accumulation of specific memory T and B cells. This process is called immune senescence, an age-related change in the immune system. In obese people, the development of metabolic diseases such as type 2 diabetes can be delayed by a low-calorie diet. In addition, such a diet also has a positive effect on the immune system. But exactly how the positive effects are mediated and what role the gut microbiome plays in this process is not yet known. ...
