A mass spectrometer device (detail): Using mass spectrometric analysis at the Max Planck Institute of Biochemistry, the researchers discovered 1484 interactions between viral and human cellular proteins. Image: Sonja Taut / MPI of Biochemistry
A mass spectrometer device (detail): Using mass spectrometric analysis at the Max Planck Institute of Biochemistry, the researchers discovered 1484 interactions between viral and human cellular proteins. Image: Sonja Taut / MPI of Biochemistry Covid-19: analysis of protein interactions as a route to new drugs - a team from the Technical University of Munich (TUM) and the Max Planck Institute of Biochemistry paints a comprehensive picture of the viral infection process. For the first time, the interaction between the coronavirus and a cell is documented at five distinct proteomics levels. This knowledge will help to gain a better understanding of the virus and find potential starting points for therapies. When a virus enters a cell, viral and cellular protein molecules begin to interact. Both the replication of the virus and the reaction of the cells are the result of complex protein signaling cascades. A team led by Andreas Pichlmair, Professor of Immunopathology of Viral Infections at the Institute of Virology at TUM, and Matthias Mann, Head of the Department of Proteomics and Signal Transduction at the Max Planck Institute of Biochemistry, has systematically recorded how human lung cells react to individual proteins of the covid-19 pathogen SARS-CoV-2 and the SARS coronavirus, the latter of which has been known for some time.
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