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Life Sciences - Health - 28.05.2020
Why developing nerve cells can take a wrong turn
Loss of ubiquitin-conjugating enzyme leads to impediment in growth of nerve cells / found between cellular machineries of protein degradation and regulation of the epigenetic landscape in human embryonic stem cells A group of scientists from CECAD, the Cluster of Excellence 'Cellular Stress Responses in Aging-Associated Diseases,' have found a mechanism by which neurodevelopmental diseases concerning neurons can be explained: The loss of a certai

Life Sciences - Chemistry - 26.05.2020
Triggered by light, a novel way to switch on an enzyme: Biotechnology
Triggered by light, a novel way to switch on an enzyme: Biotechnology
Enzymes: they are the central drivers for biochemical metabolic processes in every living cell, enabling reactions to take place efficiently. It is this very ability which allows them to be used as catalysts in biotechnology, for example to create chemical products such as pharmaceutics. A topic that is currently being widely discussed is photoinduced catalysis, in which researchers harness the ability of nature to start biochemical reactions with the aid of light.

Health - Life Sciences - 26.05.2020
High-resolution 3D view inside tumors
High-resolution 3D view inside tumors
Breast cancer is the most common cancer in women. But individual tumors can vary significantly, presenting different spatial patterns within their mass. Researchers at the Technical University of Munich (TUM) and Helmholtz Zentrum München have now succeeded in visualizing spatial changes within tumors by means of optoacoustics.

Health - Life Sciences - 13.05.2020
A disease trigger for pancreatitis has been identified
A disease trigger for pancreatitis has been identified
One factor contributing to the development of pancreatitis lies in mutations within a cell membrane ion channel that is characterized by its specific permeability for calcium ions. This groundbreaking discovery was made by a research team at Technical University of Munich (TUM), in cooperation with other groups from Germany, Japan and France.

Pharmacology - Life Sciences - 01.05.2020
An Alternative for Antibiotics
International Team of Researchers Investigates Antibacterial Effects of Antimicrobial Peptides No 073/2020 from May 01, 2020 Scientists at Cornell University, Georgetown University, and Freie Universität Berlin have analyzed and summarized to what extent antimicrobial peptides, such as those found in plants and animals, can be used as an alternative to conventional antibiotics.

Life Sciences - Health - 15.04.2020
Preserving inflammation-free phases
Preserving inflammation-free phases
Crohn's disease is a chronic inflammatory disorder of the intestine that, in most cases, relapses episodically. As of now, there is no cure for this disease. A research group led by the Technical University of Munich (TUM) has discovered a marker at a microscopic level, which can be used to identify patients that show a high probability of suffering from an inflammation recurrence in the immediate future.

Life Sciences - Health - 25.03.2020
A new mechanism triggering cell death and inflammation: a left turn that kills
Z-form nucleic acids are double-stranded DNA and RNA molecules with an unusual left-handed double helix structure, as opposed to the classical right-handed Watson-Crick double helix. Z-nucleic acids were discovered more than 40 years ago, but their biological function has remained poorly understood.

Health - Life Sciences - 17.03.2020
Blocking sugar structures on viruses and tumor cells
Blocking sugar structures on viruses and tumor cells
Coronavirus: University operations limited +++ make use of online services +++ many staff working from home +++ www.tum.de/corona Artificial sugar-binding protein may inhibit cell growth During a viral infection, viruses enter the body and multiply in its cells. Viruses often specifically attach themselves to the sugar structures of the host cells, or present characteristic sugar structures on their surface themselves.

Life Sciences - Health - 13.03.2020
Analysis of whole brain vasculature
Analysis of whole brain vasculature
Coronavirus: University operations limited +++ make use of online services +++ many staff working from home Biochemical methods and AI show even the finest capillaries Diseases of the brain are often associated with typical vascular changes. Now, scientists at LMU University Hospital Munich, Helmholtz Zentrum München and at the Technical University of Munich (TUM) have come up with a technique for visualising the structures of all the brain's blood vessels - right down to the finest capillaries - including any pathological changes.

Life Sciences - Chemistry - 12.03.2020
A molecular map for the plant sciences
A molecular map for the plant sciences
First comprehensive map of the proteome of the model plant Arabidopsis thaliana Plants are essential for life on earth. They provide food for essentially all organisms, oxygen for breathing, and they regulate the climate of the planet. Proteins play a key role in controlling all aspects of life including plants.

Life Sciences - 06.03.2020
Why Individuals Are Not Alike
Neurobiologists studied how brain development influences behavioral differences No 051/2020 from Mar 06, 2020 Neurobiologists at Freie Universität Berlin led by Bassem Hassan, Einstein BIH Visiting Fellow, in collaboration with the group led by Robin Hiesinger at the Department of Biology, Chemistry, and Pharmacy at Freie Universität Berlin, described in a study published in Science why fruit flies display individual behavioral differences despite having the same genotype and being reared in identical environmental conditions.

Environment - Life Sciences - 25.02.2020
Eat or be eaten
Eat or be eaten
Biodiversity increases the efficiency of energy use in grasslands Plants obtain their energy from the sun. Other beings rely on eating to survive. Yet how does the energy flow inside ecosystems function and are there differences between ecosystems with many species in comparison to those with few species' Researchers have now examined these questions using a holistic approach by evaluating data gathered through a large-scale biodiversity experiment.

Computer Science - Life Sciences - 19.02.2020
"A rethinking in the minds of researchers is necessary": Guest comments
The reproducibility of research results is one of the fundamental quality criteria in science. The demand for transparency of the scientific knowledge process aims to ensure the repeatability of scientific studies or experiments. The project "Opening Reproducible Research" (o2r) of the Institute for Geoinformatics of the University of Münster and the University and State Library of Münster deals with this topic.

Life Sciences - Chemistry - 13.02.2020
Body Temperature Controls Enzyme Activity
A new study at Freie Universität Berlin shows how body temperature regulates certain enzymes and biological processes No 033/2020 from Feb 13, 2020 Researchers from Freie Universität Berlin's Institute of Chemistry and Biochemistry have shown that the activity of a class of enzymes is directly controlled by subtle changes in body temperature.

Life Sciences - 12.02.2020
Lane change in the cytoskeleton
Lane change in the cytoskeleton
Transport proteins can switch between microtubule network and actin network Many amphibians and fish are able to change their color in order to better adapt to their environment. Munich-based scientists have now investigated the molecular mechanisms in the cytoskeleton necessary for this and revealed potential evolutionary paths.

Life Sciences - Health - 05.02.2020
The invisibility cloak of a fungus
The invisibility cloak of a fungus
While viruses and bacteria regularly manage to infect the human organism, fungi only very rarely succeed. The reason for this is that the human immune system can recognize them very easily because their cells are surrounded by a solid cell wall of chitin and other complex sugars. Chitin is, so to speak, the alarm signal for our immune system, to which it reacts with a whole arsenal of defensive weapons.

Life Sciences - Agronomy / Food Science - 05.02.2020
Bumble bees prefer a low-fat diet
A bumble bee's diet affects survival and reproductive capabilities Are bees dying of malnourishment? Professor Sara Diana Leonhardt examines the interactions between plants and insects with her work group at the TUM School of Life Sciences Weihenstephan. Using behavioral experiments, her team analyzes how bumble bees evaluate the quality of food sources and how foods of various qualities affect their well-being.

Environment - Life Sciences - 30.01.2020
Biological diversity as a factor of production
Biological diversity as a factor of production
Relationship between the economic value of our ecosystems and biodiversity Can the biodiversity of ecosystems be considered a factor of production? A group of researchers under the direction of the Technical University of Munich (TUM) are studying the economic benefits that farmers and foresters can obtain by focusing on several species instead of just one.

Life Sciences - Physics - 29.01.2020
Guardian angel of the eye
Guardian angel of the eye
Protective protein in the eye lens affects protein oxidation The lens of the human eye comprises a highly concentrated protein solution, which lends the lens its great refractive power. Protective proteins prevent these proteins from clumping together throughout a lifetime. A team of scientists from the Technical University of Munich (TUM) has now uncovered the precise structure of the 'A-crystallin protein and, in the process, discovered an important additional function.

Life Sciences - Chemistry - 29.01.2020
Tree-like Detergent Molecules for Membrane Proteins
Scientists at Freie Universität Berlin and University of Oxford Develop Novel Technique for the Analysis of Membrane Proteins No 017/2020 from Jan 29, 2020 Researchers at Freie Universität Berlin and the University of Oxford developed a method, which enables the gentle release of proteins from membranes.

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