Quality control in immune communication

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Cellular quality control prevents the immature IL23-alpha component of the signa
Cellular quality control prevents the immature IL23-alpha component of the signal protein interleukin 23 from leaving the cell. (Image: Sina Bohnacker / TUM) Image: Sina Bohnacker / TUM

The cells of our immune system constantly communicate with one another by exchanging complex protein molecules. A team led by researchers from the Technical University of Munich (TUM) has now revealed how dedicated cellular control proteins, referred to as chaperones, detect immature immune signaling proteins and prevent them from leaving the cell.

The body’s defenses systems have to react quickly whenever pathogens enter the organism. Intruders are identified by white blood cells which pass on the information to other immune cells. ...

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