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Health - Pharmacology - 18.12.2019
Using AI to understand the spread of cancer
Using AI to understand the spread of cancer
New deep learning algorithm DeepMACT detects the smallest metastases Researchers at the Technical University of Munich (TUM), the Helmholtz Zentrum München and the LMU Munich have developed a new algorithm that automatically detects metastases. The new technology uses artificial intelligence (AI) and even finds single disseminated cancer cells in the body of mice.

Pharmacology - Health - 16.12.2019
From cancer medication to antibiotic
From cancer medication to antibiotic
Modified cancer drug effective against multi-resistant bacteria Antibiotic-resistant bacteria are increasingly the source of deadly infections. A team of scientists from the Technical University of Munich (TUM) and the Helmholtz Center for Infection Research (HZI) in Braunschweig have now modified an approved cancer drug to develop an active agent against multidrug-resistant pathogens.

Health - 25.11.2019
Regeneration of nerve cells, 3D printing in construction
Regeneration of nerve cells, 3D printing in construction
DFG funds two new TUM transregional Collaborative Research Centers Regeneration of nerve cells, 3D printing in construction The German Research Foundation (Deutsche Forschungsgemeinschaft or DFG) is funding two new transregional Collaborative Research Centers (SFB/Transregional research alliance) involving the Technical University of Munich (TUM).

Life Sciences - Health - 18.11.2019
Antibiotics from the sea
Antibiotics from the sea
Research team cultivates marine bacteria that had previously been paid little attention and taps potential source of new antibiotics The team led by Prof. Christian Jogler of Friedrich Schiller University, Jena, has succeeded in cultivating several dozen marine bacteria in the laboratory - bacteria that had previously been paid little attention.

Health - Life Sciences - 30.10.2019
Parasite manipulates algal metabolism for its own benefit
Parasite manipulates algal metabolism for its own benefit
Pathogenic fungi attack diatoms in the ocean and trigger the formation of new, beneficial substances in the algae Microalgae can form massive assemblages in oceans, attracting many opportunistic organisms; these are capable of eliminating the entire algal population within a short time. However, the underlying mechanisms of this watery arms race are largely unknown.

Pharmacology - Health - 21.10.2019
Benefit and risk
Benefit and risk
Meta-analysis draws a heterogeneous picture of drug-coated balloon angioplasty Scientists of Jena University Hospital, Germany, conducted a meta-analysis sought to evaluate benefit and risk of paclitaxel-coated balloon angioplasty compared to plain old balloon angioplasty as therapy of intermittent claudication.

Pharmacology - Health - 14.10.2019
Inactive receptor renders immunotherapies ineffective
Inactive receptor renders immunotherapies ineffective
The aim of immunotherapies is to enable the immune system once again to fight cancer on its own. Drugs known as checkpoint inhibitors are already in clinical use for this purpose. However, they are only effective in about one third of patients. Based on analysis of human tissue samples, a team from the Technical University of Munich (TUM) has now discovered one reason why this is so: an inactive receptor in cancer cells prevents the drugs from reactivating the immune system.

Health - Life Sciences - 09.10.2019
Tuberculosis: New insights into the pathogen
Researchers at the University of Würzburg and the Spanish Cancer Research Centre have gained new insights into the pathogen that causes tuberculosis. Tuberculosis is a highly contagious infectious disease that is typically spread through aerosols and mainly affects the lungs. According to the World Health Organization (WHO), an estimated 1.7 million people die from such an infection worldwide every year.

Health - Physics - 02.10.2019
Tracking the HI virus
Tracking the HI virus
Researchers make visible, how AIDS pathogens multiply in the body In order to treat diseases better, we must understand how they arise.

Health - Life Sciences - 02.10.2019
Weak spot in pathogenic bacteria
Weak spot in pathogenic bacteria
Antibiotics are still the most important weapon for combatting bacterial infections. But medical science is running out of "ammunition" because of more and more frequently occurring resistances. A research team has now elucidated the structure of the proteolytic complex ClpX-ClpP. This is a key to development of innovative antibiotics which target the degradation process of defective proteins in bacteria.

Pharmacology - Health - 02.10.2019
New approach to pain treatment in diseases of the pancreas
New approach to pain treatment in diseases of the pancreas
One of the worst symptoms associated with inflammation or cancer of the pancreas is severe chronic pain. Pancreatic pain is difficult to treat, because many painkillers prove ineffective in pancreatic patients. In a recent study, a team at the Technical University of Munich (TUM) discovered the cause of this phenomenon for the first time: a particular neuroenzyme in the body is present in the nerves of the organ in high concentrations.

Life Sciences - Health - 01.10.2019
A timekeeper for siesta
External stimuli can rearrange the hierarchy of neuronal networks and influence behaviour. This was demonstrated by scientists from the universities of Würzburg and Brandeis using the circadian clock of the fruit fly as an example. Circadian clocks must be flexible and they must be able to adapt to varying environmental conditions.

Life Sciences - Health - 24.09.2019
Specific immune response of beetles adapts to bacteria
Specific immune response of beetles adapts to bacteria
When the immune system fends off pathogens, this can happen in a very wide variety of ways. For example, the immune system's memory is able to distinguish a foreign protein with which the organism has already come into contact from another and to react with a corresponding antibody. Researchers have now investigated experimentally whether this ability of the immune system to specifically fend off pathogens can adapt in the course of evolution.

Life Sciences - Health - 19.09.2019
"Genetic variants associated with educational attainment" can also have positive implications for lifestyle
A German and British research team lead by the Technical University of Munich (TUM) has examined the interplay between genetics, cardiovascular disease and educational attainment in a major population study. Genetic variants which had been linked to educational attainment in other studies were observed in the subjects.

Health - Life Sciences - 18.09.2019
Interactions between bacteria and parasites
Interactions between bacteria and parasites
A team at the Technical University of Munich (TUM) has completed the first study of the effects of a simultaneous infection with blood flukes (schistosomes) and the bacterium Helicobacter pylori - a fairly common occurrence in some parts of the world. They identified a complex interaction which resulted - among other effects - in a weakening of the adverse impact of the pathogens acting individually.

Pharmacology - Health - 12.09.2019
Asthma Medication as Doping Agent?
Prospective Students Students and Doctorate Alumni and Supporters Continuing Education Study by Ulm University Medical Center examines effect of asthma medication on athletic performance / Cooperation with Freie Universität Berlin and German Sport University Cologne No 265/2019 from Sep 12, 2019 A new study conducted this year by the Sports and Rehabilitation Medicine Unit at Ulm University Medical Center is examining how asthma medications affect athletic performance in professional athletes.

Health - Life Sciences - 02.09.2019
New method reformulates pathogens into the body's allies
New method reformulates pathogens into the body’s allies
Any agreement which entails benefits for both sides is called a win-win situation. This is precisely the result intended for the long-term cooperation and licensing agreement which the Institute of Infectiology at the University of Münster has now signed with an American biomedical company. The objective of the collaboration with Innate Biologics in Philadelphia, Pennsylvania, is to improve the possibilities for treating inflammatory skin diseases and autoimmune diseases - and, in the long term, to develop new medications.

Health - 02.09.2019
Who benefits from a defibrillator?
Implantable defibrillators can save lives, but also harbor risks. A major European study headed by three researchers from the Technical University of Munich (TUM), LMU München and University Medical Center Göttingen has found that a special ECG method can help to identify the patients most likely to benefit from these devices.

Life Sciences - Health - 16.08.2019
Predicting Protein Functions
Proteins perform vital tasks in the body, such as regulating metabolism and transmitting signals. Researchers from the Berlin Institute of Health (BIH) and Heidelberg University have now developed an intelligent neural network that uses algorithms to predict the functions of proteins. The scientists used a trick to observe how the network makes its predictions.

Health - Environment - 25.07.2019
HIV Spreads Through Direct Cell-To-Cell Contact
HIV Spreads Through Direct Cell-To-Cell Contact
The spread of pathogens like the human immunodeficiency virus (HIV) is often studied in a test tube, i.e. in two-dimensional cell cultures, even though it hardly reflects the much more complex conditions in the human body. Using innovative cell culture systems, quantitative image analysis, and computer simulations, an interdisciplinary team of scientists from Heidelberg University has now explored how HIV spreads in three-dimensional tissue-like environments.
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