Cells divide after activation of YAP (green staining) - but only if the MMB protein complex is intact. (Image: AG Gaubatz)
06/19/2019 - When two proteins work together, this worsens the prognosis for lung cancer patients: their chances of survival are particularly poor in this case. In malignant tumours, the cells usually proliferate quickly and uncontrollably. A research team from the Biocenter of Julius-Maximilians-Universität (JMU) Würzburg in Bavaria, Germany, has discovered that two important regulators of cell division can interact in this process. If this is the case, affected patients have particularly poor chances of survival. A special form of lung cancer was investigated. The JMU team led by Professor Stefan Gaubatz and Dr. Grit Pattschull from the Chair of Biochemistry and Molecular Biology II analysed the activities of the protein YAP and the protein complex MMB (Myb-MuvB). According to the researchers, the former protein is only able to initiate cell division when it interacts with a subunit of the MMB complex.
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